Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2022 Jan 10;22(1):18.
doi: 10.1186/s12871-021-01555-8.

Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective study

Jia-Gui Ma  1   2 , Bo Zhu  2 , Li Jiang  2   3 , Qi Jiang  2 , Xiu-Ming Xi  4
Affiliations
Observational Study

Gender- and age-based differences in outcomes of mechanically ventilated ICU patients: a Chinese multicentre retrospective study

Jia-Gui Ma et al. BMC Anesthesiol. .

Abstract

Background: Previous studies have suggested that the gender and/or age of a patient may influence the clinical outcomes of critically ill patients. Our aim was to determine whether there are gender- and age-based differences in clinical outcomes for mechanically ventilated patients in intensive care units (ICUs).

Methods: We performed a multicentre retrospective study involving adult patients who were admitted to the ICU and received at least 24 h of mechanical ventilation (MV). The patients were divided into two groups based on gender and, subsequently, further grouped based on gender and age < or ≥ 65 years. The primary outcome measure was hospital mortality.

Results: A total of 853 mechanically ventilated patients were evaluated. Of these patients, 63.2% were men and 61.5% were ≥ 65 years of age. The hospital mortality rate for men was significantly higher than that for women in the overall study population (P = 0.042), and this difference was most pronounced among elderly patients (age ≥ 65 years; P = 0.006). The durations of MV, ICU lengths of stay (LOS), and hospital LOS were significantly longer for men than for women among younger patients (P ≤ 0.013) but not among elderly patients. Multivariate logistic regression analysis revealed that male gender was independently associated with hospital mortality among elderly patients but not among younger patients.

Conclusions: There were important gender- and age-based differences in the outcomes among mechanically ventilated ICU patients. The combination of male gender and advanced age is strongly associated with hospital mortality.

Keywords: Age; Gender; Intensive care unit; Mechanical ventilation; Mortality; Outcome.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Du B, An Y, Kang Y, Yu X, Zhao M, Ma X, et al. Characteristics of critically ill patients in ICUs in mainland China. Crit Care Med. 2013;41(1):84–92. doi: 10.1097/CCM.0b013e31826a4082. - DOI - PubMed
    1. Metnitz PG, Metnitz B, Moreno RP, Bauer P, Del Sorbo L, Hoermann C, et al. Epidemiology of mechanical ventilation: analysis of the SAPS 3 database. Intensive Care Med. 2009;35(5):816–825. doi: 10.1007/s00134-009-1449-9. - DOI - PubMed
    1. Fowler RA, Sabur N, Li P, Juurlink DN, Pinto R, Hladunewich MA, et al. Sex-and age-based differences in the delivery and outcomes of critical care. CMAJ. 2007;177(12):1513–1519. doi: 10.1503/cmaj.071112. - DOI - PMC - PubMed
    1. Sacanella E, Pérez-Castejón JM, Nicolás JM, Masanés F, Navarro M, Castro P, et al. Mortality in healthy elderly patients after ICU admission. Intensive Care Med. 2009;35(3):550–555. doi: 10.1007/s00134-008-1345-8. - DOI - PubMed
    1. Farfel JM, Franca SA, Sitta Mdo C, Filho WJ, Carvalho CR. Age, invasive ventilatory support and outcomes in elderly patients admitted to intensive care units. Age Ageing. 2009;38(5):515–520. doi: 10.1093/ageing/afp119. - DOI - PubMed

Publication types

LinkOut - more resources