Ketogenic diet for mitochondrial disease: potential role in treating the Multiple Symmetric Lipomatosis phenotype associated with the common MT-TK genetic mutation

Affiliations

¹ Adult Metabolic Diseases Clinic, Vancouver General Hospital and Department of Pathology, Faculty of Medicine, Gordon & Leslie Diamond Health Care Centre, University of British Columbia, 4th Floor, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada. amattman@providencehealth.bc.ca.
² , Vancouver, Canada.
³ Adult Metabolic Diseases Clinic, Vancouver General Hospital and Division of Neurology, Faculty of Medicine, University of British Columbia, 4th Floor, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.
⁴ Department of Radiology, St Paul's Hospital, 1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada.
⁵ Department of Biomedical Physiology & Kinesiology, Simon Fraser University, 8888 University Drive Burnaby, V5A 1S6, Burnaby, B.C., Canada.
⁶ Adult Metabolic Diseases Clinic, Vancouver General Hospital, 4th Floor, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.
⁷ Centre for Heart Lung Innovation, St Paul's Hospital and, Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, 1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada.
⁸ Centre for Heart Lung Innovation, St Paul's Hospital and Department of Physical Therapy, Faculty of Medicine, University of British Columbia, 1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada.

Comment

Andre Mattman et al. Orphanet J Rare Dis. 2022.

. 2022 Jan 10;17(1):12.

doi: 10.1186/s13023-021-02164-x.

¹ Adult Metabolic Diseases Clinic, Vancouver General Hospital and Department of Pathology, Faculty of Medicine, Gordon & Leslie Diamond Health Care Centre, University of British Columbia, 4th Floor, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada. amattman@providencehealth.bc.ca.
² , Vancouver, Canada.
³ Adult Metabolic Diseases Clinic, Vancouver General Hospital and Division of Neurology, Faculty of Medicine, University of British Columbia, 4th Floor, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.
⁴ Department of Radiology, St Paul's Hospital, 1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada.
⁵ Department of Biomedical Physiology & Kinesiology, Simon Fraser University, 8888 University Drive Burnaby, V5A 1S6, Burnaby, B.C., Canada.
⁶ Adult Metabolic Diseases Clinic, Vancouver General Hospital, 4th Floor, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.
⁷ Centre for Heart Lung Innovation, St Paul's Hospital and, Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, 1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada.
⁸ Centre for Heart Lung Innovation, St Paul's Hospital and Department of Physical Therapy, Faculty of Medicine, University of British Columbia, 1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada.

No abstract available

Conflict of interest statement

The authors declare that they have no competing interests.

Ketogenic diet for mitochondrial disease: a systematic review on efficacy and safety.
Zweers H, van Wegberg AMJ, Janssen MCH, Wortmann SB. Zweers H, et al. Orphanet J Rare Dis. 2021 Jul 3;16(1):295. doi: 10.1186/s13023-021-01927-w. Orphanet J Rare Dis. 2021. PMID: 34217336 Free PMC article.

1. Zweers H, van Wegberg AMJ, Janssen MCH, Wortmann SB. Ketogenic diet for mitochondrial disease: a systematic review on efficacy and safety. Orphanet J Rare Dis. 2021;16(1):295. doi: 10.1186/s13023-021-01927-w. - DOI - PMC - PubMed
1. Nadeau E, Mezei MM, Cresswell M, Zhao S, Bosdet T, Sin DD, Guenette JA, Dupuis I, Allin E, Clarke DC, Mattman A. Self-initiated lifestyle interventions lead to potential insight into an effective, alternative, non-surgical therapy for mitochondrial disease associated multiple symmetric lipomatosis. Mitochondrion. 2020;52:183–189. doi: 10.1016/j.mito.2020.03.009. - DOI - PubMed