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Review
. 2022 Jan 10;13(1):10.
doi: 10.1186/s13287-021-02686-y.

Context-dependent transcriptional regulations of YAP/TAZ in stem cell and differentiation

Juan Luo  1 , Peng Li  2   3
Affiliations
Review

Context-dependent transcriptional regulations of YAP/TAZ in stem cell and differentiation

Juan Luo et al. Stem Cell Res Ther. .

Abstract

Hippo pathway is initially identified as a master regulator for cell proliferation and organ size control, and the subsequent researches show this pathway is also involved in development, tissue regeneration and homeostasis, inflammation, immunity and cancer. YAP/TAZ, the downstream effectors of Hippo pathway, usually act as coactivators and are dependent on other transcription factors to mediate their transcriptional outputs. In this review, we will first provide an overview on the core components and regulations of Hippo pathway in mammals, and then systematically summarize the identified transcriptional factors or partners that are responsible for the transcriptional output of YAP/TAZ in stem cell and differentiation. More than that, we will discuss the potential applications and future directions based on these findings.

Keywords: Context-dependent; Hippo pathway; Stem cell and differentiation; Transcriptional output; YAP/TAZ.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Hippo pathway components in Mammals and Drosophila
Fig. 2
Fig. 2
The regulations and upstream regulators of Hippo pathway in Mammals
See this image and copyright information in PMC

References

    1. Xu T, Wang W, Zhang S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development. 1995;121:1053–1063. - PubMed
    1. Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 1995;9:534–546. - PubMed
    1. Tapon N, et al. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell. 2002;110:467–478. - PubMed
    1. Kango-Singh M, et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development. 2002;129:5719–5730. - PubMed
    1. Jia J, Zhang W, Wang B, Trinko R, Jiang J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev. 2003;17:2514–2519. - PMC - PubMed

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