Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1987 Nov;92(3):483-5.
doi: 10.1111/j.1476-5381.1987.tb11347.x.

Differential selectivity of endothelium-derived relaxing factor and nitric oxide in smooth muscle

K Shikano  1 , E H Ohlstein, B A Berkowitz
Affiliations
Comparative Study

Differential selectivity of endothelium-derived relaxing factor and nitric oxide in smooth muscle

K Shikano et al. Br J Pharmacol. 1987 Nov.

Abstract

The selectivity of endothelium-derived relaxing factor (EDRF) and nitric oxide (NO) on smooth muscle relaxation was examined and compared. EDRF released from was examined and compared. EDRF released from bovine pulmonary arterial endothelium (BPAE) in culture and NO were superfused over vascular, tracheal, gastrointestinal and uterine smooth muscle. EDRF relaxed vascular smooth muscle but not tracheal, gastrointestinal or uterine smooth muscle. NO relaxed vascular and gastrointestinal smooth muscle but not tracheal or uterine smooth muscle. There was a differential selectivity between the relaxant effect of EDRF and NO on smooth muscle.

PubMed Disclaimer

References

    1. Nature. 1980 Nov 27;288(5789):373-6 - PubMed
    1. Nature. 1986 Apr 3-9;320(6061):454-6 - PubMed
    1. Nature. 1987 Jun 11-17;327(6122):524-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Dec;83(23):9164-8 - PubMed
    1. Am J Physiol. 1986 May;250(5 Pt 2):H822-7 - PubMed

Publication types

LinkOut - more resources