Unsprung traps keep PARP inhibitors effective

doi:10.1038/s41556-021-00819-2

Comment

. 2022 Jan;24(1):2-4.

doi: 10.1038/s41556-021-00819-2.

Unsprung traps keep PARP inhibitors effective

Peter M Brownlee¹, Luc Provencher¹, Aaron A Goodarzi²

Affiliations

¹ Departments of Biochemistry and Molecular Biology and Oncology, Robson DNA Science Centre, Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
² Departments of Biochemistry and Molecular Biology and Oncology, Robson DNA Science Centre, Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. a.goodarzi@ucalgary.ca.

PMID: 35013555
DOI: 10.1038/s41556-021-00819-2

Comment

Unsprung traps keep PARP inhibitors effective

Peter M Brownlee et al. Nat Cell Biol. 2022 Jan.

. 2022 Jan;24(1):2-4.

doi: 10.1038/s41556-021-00819-2.

Authors

Peter M Brownlee¹, Luc Provencher¹, Aaron A Goodarzi²

Affiliations

¹ Departments of Biochemistry and Molecular Biology and Oncology, Robson DNA Science Centre, Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
² Departments of Biochemistry and Molecular Biology and Oncology, Robson DNA Science Centre, Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. a.goodarzi@ucalgary.ca.

PMID: 35013555
DOI: 10.1038/s41556-021-00819-2

No abstract available

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The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
Krastev DB, Li S, Sun Y, Wicks AJ, Hoslett G, Weekes D, Badder LM, Knight EG, Marlow R, Pardo MC, Yu L, Talele TT, Bartek J, Choudhary JS, Pommier Y, Pettitt SJ, Tutt ANJ, Ramadan K, Lord CJ. Krastev DB, et al. Nat Cell Biol. 2022 Jan;24(1):62-73. doi: 10.1038/s41556-021-00807-6. Epub 2022 Jan 10. Nat Cell Biol. 2022. PMID: 35013556 Free PMC article.

Cited by

CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair.
Provencher L, Nartey W, Brownlee PM, Atkins AW, Gagné JP, Baudrier L, Ting NSY, Piett CG, Fang S, Pearson DD, Moore S, Billon P, Nagel ZD, Poirier GG, Williams GJ, Goodarzi AA. Provencher L, et al. Nat Commun. 2025 Jan 25;16(1):1026. doi: 10.1038/s41467-025-56085-5. Nat Commun. 2025. PMID: 39863586 Free PMC article.

References

1. Hu, Y. et al. Cancer Discov. 4, 1430–1447 (2014). - DOI
1. Moore, S. et al. Nat. Commun. 10, 241 (2019). - DOI
1. Lord, C. J. et al. Science 355, 1152–1158 (2017). - DOI
1. Murai, J. et al. Cancer Res. 72, 5588–5599 (2012). - DOI
1. Krastev, D. B. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00807-6 (2021).

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[1] Hu, Y. et al. Cancer Discov. 4, 1430–1447 (2014). - DOI

[2] Hu, Y. et al. Cancer Discov. 4, 1430–1447 (2014). - DOI

[3] Moore, S. et al. Nat. Commun. 10, 241 (2019). - DOI

[4] Moore, S. et al. Nat. Commun. 10, 241 (2019). - DOI

[5] Lord, C. J. et al. Science 355, 1152–1158 (2017). - DOI

[6] Lord, C. J. et al. Science 355, 1152–1158 (2017). - DOI

[7] Murai, J. et al. Cancer Res. 72, 5588–5599 (2012). - DOI

[8] Murai, J. et al. Cancer Res. 72, 5588–5599 (2012). - DOI

[9] Krastev, D. B. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00807-6 (2021).

[10] Krastev, D. B. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00807-6 (2021).

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Unsprung traps keep PARP inhibitors effective

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Unsprung traps keep PARP inhibitors effective

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