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Comment
. 2022 Jan;24(1):2-4.
doi: 10.1038/s41556-021-00819-2.

Unsprung traps keep PARP inhibitors effective

Peter M Brownlee  1 , Luc Provencher  1 , Aaron A Goodarzi  2
Affiliations
Comment

Unsprung traps keep PARP inhibitors effective

Peter M Brownlee et al. Nat Cell Biol. 2022 Jan.
No abstract available

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Comment on

  • The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
    Krastev DB, Li S, Sun Y, Wicks AJ, Hoslett G, Weekes D, Badder LM, Knight EG, Marlow R, Pardo MC, Yu L, Talele TT, Bartek J, Choudhary JS, Pommier Y, Pettitt SJ, Tutt ANJ, Ramadan K, Lord CJ. Krastev DB, et al. Nat Cell Biol. 2022 Jan;24(1):62-73. doi: 10.1038/s41556-021-00807-6. Epub 2022 Jan 10. Nat Cell Biol. 2022. PMID: 35013556 Free PMC article.

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    1. Lord, C. J. et al. Science 355, 1152–1158 (2017). - DOI
    1. Murai, J. et al. Cancer Res. 72, 5588–5599 (2012). - DOI
    1. Krastev, D. B. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00807-6 (2021).

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