Substituting SABR for systemic therapy in oligometastatic renal cell carcinoma - buying time or time to change?

Shankar Siva^{1

2}, Alexander V Louie³

Affiliations

¹ Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. shankar.siva@petermac.org.
² Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. shankar.siva@petermac.org.
³ Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada.

Comment

Shankar Siva et al. Nat Rev Urol. 2022 Apr.

. 2022 Apr;19(4):197-198.

doi: 10.1038/s41585-021-00560-3.

Shankar Siva^{1

2}, Alexander V Louie³

¹ Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. shankar.siva@petermac.org.
² Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. shankar.siva@petermac.org.
³ Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada.

No abstract available

Comment on

Definitive radiotherapy in lieu of systemic therapy for oligometastatic renal cell carcinoma: a single-arm, single-centre, feasibility, phase 2 trial.
Tang C, Msaouel P, Hara K, Choi H, Le V, Shah AY, Wang J, Jonasch E, Choi S, Nguyen QN, Das P, Prajapati S, Yu Z, Khan K, Powell S, Murthy R, Sircar K, Tannir NM. Tang C, et al. Lancet Oncol. 2021 Dec;22(12):1732-1739. doi: 10.1016/S1470-2045(21)00528-3. Epub 2021 Oct 28. Lancet Oncol. 2021. PMID: 34717797 Free PMC article. Clinical Trial.

1. Barney, J. D. & Churchill, E. J. Adenocarcinoma of the kidney with metastasis to the lung: cured by nephrectomy and lobectomy. J. Urol. 42, 269–276 (1939). - DOI
1. Siva, S. et al. Radiotherapy for renal cell carcinoma: renaissance of an overlooked approach. Nat. Rev. Urol. 14, 549–563 (2017). - DOI
1. Deschavanne, P. J. & Fertil, B. A review of human cell radiosensitivity in vitro. Int. J. Radiat. Oncol. Biol. Phys. 34, 251–266 (1996). - DOI
1. Zaorsky, N. G., Lehrer, E. J., Kothari, G., Louie, A. V. & Siva, S. Stereotactic ablative radiation therapy for oligometastatic renal cell carcinoma (SABR ORCA): a meta-analysis of 28 studies. Eur. Urol. Oncol. 2, 515–523 (2019). - DOI
1. Motzer, R. J. et al. Kidney cancer, version 2.2017, NCCN clinical practice guidelines in oncology. J. Natl Compr. Canc. Netw. 15, 804–834 (2017). - DOI