Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Dec;28(12):1648-52.
doi: 10.1136/gut.28.12.1648.

Effect of recombinant interleukin 2 on hepatitis B e antigen positive chronic hepatitis

M Onji  1 , H Kondoh, N Horiike, S Yamaguchi, Y Ogawa, I Kumon, Y Ohta
Affiliations

Effect of recombinant interleukin 2 on hepatitis B e antigen positive chronic hepatitis

M Onji et al. Gut. 1987 Dec.

Abstract

Eleven patients with hepatitis B (HB) virus related chronic hepatitis were treated with recombinant interleukin 2 (rIL 2). Two hundred and fifty to 1000 units were given intravenously once daily for seven to 28 days. In five patients serum glutamic pyruvic transaminase activity rose transiently. Six patients showed a decrease in HBV DNA polymerase. One patient lost HBs, e antigens (Ags) and gained anti-HBs, e antibodies, while one lost HBs Ag and another HBe Ag. 2'-5' oligoadenylate synthetase activity in mononuclear cells in the peripheral blood did not change during treatment. The number of CD4 positive (helper/inducer) cells and natural killer cell activity increased after therapy (p less than 0.05, p less than 0.01). These results suggest that rIL 2 acts as an immunomodulatory agent enhancing host immune activity and may be beneficial in patients with chronic HB virus infection.

PubMed Disclaimer

References

    1. J Virol. 1973 Nov;12(5):995-1005 - PubMed
    1. Transplantation. 1976 Jun;21(6):468-76 - PubMed
    1. Nature. 1977 Jul 14;268(5616):154-6 - PubMed
    1. Gut. 1986 Dec;27(12):1498-501 - PubMed
    1. J Immunol. 1984 Nov;133(5):2442-5 - PubMed