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Review
. 2022 Apr 6;28(20):e202104371.
doi: 10.1002/chem.202104371. Epub 2022 Feb 15.

Enantioselective C-H Functionalization Reactions under Gold Catalysis

Avishek Das  1 , Nitin T Patil  1
Affiliations
Review

Enantioselective C-H Functionalization Reactions under Gold Catalysis

Avishek Das et al. Chemistry. .

Abstract

Transition metal-catalyzed enantioselective functionalization of ubiquitous C-H bonds has proven to be promising field as it offers the construction of chiral molecular complexity in a step- and atom-economical manner. In recent years, gold has emerged as an attractive contender for catalyzing such reactions. The unique reactivities and selectivities offered by gold catalysts have been exploited to access numerous asymmetric transformations based on gold-catalyzed C-H functionalization processes. Herein, this review critically highlights the major advances and discoveries made in the enantioselective C-H functionalization under gold catalysis which is accompanied by mechanistic insights at appropriate places.

Keywords: C−H functionalization; chiral ligands; enantioselective synthesis; gold catalysis; merged gold/organo catalysis.

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References

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