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. 2022 Jan 4;5(1):e2142725.
doi: 10.1001/jamanetworkopen.2021.42725.

Estimating COVID-19 Infections, Hospitalizations, and Deaths Following the US Vaccination Campaigns During the Pandemic

Affiliations

Estimating COVID-19 Infections, Hospitalizations, and Deaths Following the US Vaccination Campaigns During the Pandemic

Thomas N Vilches et al. JAMA Netw Open. .

Abstract

This decision analytic modeling study uses a simulation model to evaluate the association of US COVID-19 vaccination campaigns with infections, hospitalizations, and deaths.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure 1.
Figure 1.. Association of COVID-19 Vaccination With Infections
Projected daily incidence per 100 000 population caused by different variants of SARS-CoV-2 with actual vaccination rollout in the US, a temporal vaccination rate reduced to half of the actual pace, and without vaccination. Black dots are reported incidence per 100 000 population, and shaded areas represent the range of uncertainty (95% CrI) in the projections.
Figure 2.
Figure 2.. Association of COVID-19 Vaccination With Disease Outcomes
Projected additional hospitalizations (A) and deaths (B) that would have occurred under the counterfactual scenarios of no vaccination and 50% reduced daily vaccination rate. Bars indicate the mean of estimates and error bars represent the 95% credible intervals.

References

    1. Polack FP, Thomas SJ, Kitchin N, et al. ; C4591001 Clinical Trial Group . Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383(27):2603-2615. doi:10.1056/NEJMoa2034577 - DOI - PMC - PubMed
    1. Baden LR, El Sahly HM, Essink B, et al. ; COVE Study Group . Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384(5):403-416. doi:10.1056/NEJMoa2035389 - DOI - PMC - PubMed
    1. Sadoff J, Gray G, Vandebosch A, et al. ; ENSEMBLE Study Group . Safety and efficacy of single-dose Ad26.COV2.S vaccine against COVID-19. N Engl J Med. 2021;384(23):2187-2201. doi:10.1056/NEJMoa2101544 - DOI - PMC - PubMed
    1. Moghadas SM, Sah P, Vilches TN, Galvani AP. Can the USA return to pre-COVID-19 normal by July 4? Lancet Infect Dis. 2021;21(8):1073-1074. doi:10.1016/S1473-3099(21)00324-8 - DOI - PMC - PubMed
    1. Sah P, Fitzpatrick MC, Zimmer CF, et al. . Asymptomatic SARS-CoV-2 infection: a systematic review and meta-analysis. Proc Natl Acad Sci U S A. 2021;118(34):e2109229118. doi:10.1073/pnas.2109229118 - DOI - PMC - PubMed

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