Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Feb;36(2):203-204.
doi: 10.1007/s40263-021-00891-0. Epub 2022 Jan 11.

Comment on "Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status"

Affiliations
Comment

Comment on "Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status"

Marco Pappagallo et al. CNS Drugs. 2022 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Marco Pappagallo, Charles Inturrisi and Paolo Manfredi are paid consultants for Relmada Therapeutics. Charles Inturrisi and Paolo Manfredi are inventors on patents and patent applications related to dextromethadone.

Comment in

Comment on

References

    1. Henter ID, Park LT, Zarate CA., Jr Novel glutamatergic modulators for the treatment of mood disorders: current status. CNS Drugs. 2021;35(5):527–543. doi: 10.1007/s40263-021-00816-x. - DOI - PMC - PubMed
    1. Eddy NB, Halbach H, Braenden OJ. Synthetic substances with morphine-like effect: clinical experience; potency, side-effects, addiction liability. Bull World Health Organ. 1957;17:569–863. - PMC - PubMed
    1. Gorman AL, Elliott KJ, Inturrisi CE. The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord. Neurosci Lett. 1997;223:5–8. doi: 10.1016/S0304-3940(97)13391-2. - DOI - PubMed
    1. Isbell H, Eisenman AJ. The addiction liability of some drugs of the methadone series. J Pharmacol Exp Ther. 1948;93:305–313. - PubMed
    1. Lemberg K, Kontinen VK, Viljakka K, et al. Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. Anesth Analg. 2006;102:1768–1774. doi: 10.1213/01.ane.0000205751.88422.41. - DOI - PubMed