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Book

Castleman Disease

Nimra Ehsan  1 , Farah Zahra  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Castleman Disease

Nimra Ehsan et al.
Free Books & Documents

Excerpt

Castleman disease (CD) is a rare, nonclonal lymphoproliferative disorder having distinct subtypes depending on its etiology, pathology, and clinical presentation. It can affect lymph nodes of any body region, imitating both benign and malignant malformations, including the neck, chest, abdomen, and pelvis. Pathologically it can be classified as hyaline vascular type (HV-CD), plasma cell type, mixed type, and human herpesvirus (HHV)-8 associated Castleman disease.

Clinically it manifests as the more common unicentric ( localized or unifocal ) Castleman disease (UCD) and the less common multicentric ( generalized or multifocal ) Castleman disease (MCD).

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Conflict of interest statement

Disclosure: Nimra Ehsan declares no relevant financial relationships with ineligible companies.

Disclosure: Farah Zahra declares no relevant financial relationships with ineligible companies.

References

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    1. Simpson D. Epidemiology of Castleman Disease. Hematol Oncol Clin North Am. 2018 Feb;32(1):1-10. - PubMed

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