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Comment
. 2022 Jan 10;32(1):R52-R54.
doi: 10.1016/j.cub.2021.11.029.

Cell competition: Clonal competition protects against early tumorigenesis

Joshua D'Ambrogio  1 , Liam Hill  1 , Catherine Hogan  2
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Free article
Comment

Cell competition: Clonal competition protects against early tumorigenesis

Joshua D'Ambrogio et al. Curr Biol. .
Free article

Abstract

Aging tissues accumulate somatic mutations, yet cancer occurrence is relatively rare. A new study provides compelling evidence for why this may be the case and reveals that competition between mutant clones in oesophageal tissues protects against early tumorigenesis.

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  • Mutant clones in normal epithelium outcompete and eliminate emerging tumours.
    Colom B, Herms A, Hall MWJ, Dentro SC, King C, Sood RK, Alcolea MP, Piedrafita G, Fernandez-Antoran D, Ong SH, Fowler JC, Mahbubani KT, Saeb-Parsy K, Gerstung M, Hall BA, Jones PH. Colom B, et al. Nature. 2021 Oct;598(7881):510-514. doi: 10.1038/s41586-021-03965-7. Epub 2021 Oct 13. Nature. 2021. PMID: 34646013 Free PMC article.

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