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Comment
. 2022 Jan 10;40(1):11-13.
doi: 10.1016/j.ccell.2021.12.010.

Fine-tuning CARs for best performance

Alastair Hotblack  1 , Karin Straathof  2
Affiliations
Free article
Comment

Fine-tuning CARs for best performance

Alastair Hotblack et al. Cancer Cell. .
Free article

Abstract

Chimeric antigen receptors (CARs) allow redirection of T cells against any surface antigen. However, CARs require optimization to achieve activity against low-density antigens. Heitzeneder et al. perform an iterative adjustment of CAR components to reach a design for targeting cerebroglycan (GPC2) that shows potent pre-clinical activity in neuroblastoma models.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity.
    Heitzeneder S, Bosse KR, Zhu Z, Zhelev D, Majzner RG, Radosevich MT, Dhingra S, Sotillo E, Buongervino S, Pascual-Pasto G, Garrigan E, Xu P, Huang J, Salzer B, Delaidelli A, Raman S, Cui H, Martinez B, Bornheimer SJ, Sahaf B, Alag A, Fetahu IS, Hasselblatt M, Parker KR, Anbunathan H, Hwang J, Huang M, Sakamoto K, Lacayo NJ, Klysz DD, Theruvath J, Vilches-Moure JG, Satpathy AT, Chang HY, Lehner M, Taschner-Mandl S, Julien JP, Sorensen PH, Dimitrov DS, Maris JM, Mackall CL. Heitzeneder S, et al. Cancer Cell. 2022 Jan 10;40(1):53-69.e9. doi: 10.1016/j.ccell.2021.12.005. Epub 2021 Dec 30. Cancer Cell. 2022. PMID: 34971569 Free PMC article.

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