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Comment
. 2022 Jan 10;40(1):20-22.
doi: 10.1016/j.ccell.2021.12.011.

A roadmap for driving CAR T cells toward the oncogenic immunopeptidome

Melita Irving  1 , Vincent Zoete  2 , Michal Bassani-Sternberg  3 , George Coukos  3
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Comment

A roadmap for driving CAR T cells toward the oncogenic immunopeptidome

Melita Irving et al. Cancer Cell. .
Free article

Abstract

A critical barrier to CAR T cell therapy is the paucity of target antigens that are broadly and stably expressed exclusively in tumors. In their comprehensive multi-omics and pre-clinical study, Yarmarkovich et al. provide proof of principle for the development and efficacy of peptide centric (PC)-CARs targeting the oncogenic immunopeptidome of neuroblastoma.

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Conflict of interest statement

Declaration of interests V.Z. is a consultant for Cellestia Biotech. G.C. has received grants or research support or is coinvestigator in clinical trials by Bristol-Myers-Squibb, Celgene, Boehringer Ingelheim, Roche, Tigen Pharma, Iovance, and Kite. The institution of G.C. (CHUV) has received honoraria for consultations or presentations by G.C. from Roche, Genentech, BMS, AstraZeneca, Sanofi-Aventis, Nextcure, and GeneosTx. G.C. has patents in the domain of antibodies and vaccines targeting the tumor vasculature as well as technologies related to T cell expansion and engineering for T cell therapy. G.C. receives royalties from the University of Pennsylvania.

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