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. 2022 Mar;27(3):217-225.
doi: 10.1111/resp.14202. Epub 2022 Jan 11.

Sarcoidosis-related mortality and the impact of corticosteroid treatment: A population-based cohort study

Melina Gade Sikjaer  1 , Ole Hilberg  1   2 , Rikke Ibsen  3 , Anders Løkke  1   2
Affiliations

Sarcoidosis-related mortality and the impact of corticosteroid treatment: A population-based cohort study

Melina Gade Sikjaer et al. Respirology. 2022 Mar.

Abstract

Background and objective: The aims of this national cohort study were: (1) to evaluate mortality in patients with sarcoidosis, stratified by gender, age and systemic corticosteroid (SC) treatment and (2) to characterize comorbidities in this cohort.

Methods: Patients diagnosed with sarcoidosis from 2001 to 2015 were identified in the Danish National Patient Registry. Subgroup analyses were performed on cases treated/not treated with SCs within 3 years of the initial sarcoidosis diagnosis (as a proxy for disease severity). The Deyo-Charlson Comorbidity Index was used to evaluate pre-diagnostic comorbidity. Cases were matched (1:4) with controls from the general population.

Results: We identified 9795 cases with sarcoidosis. Mean age was 46.5 ± 15.9 years and 55% were male. The adjusted hazard ratio (HR) for death was 1.48 (95% CI 1.31-1.68). Mortality was higher than for controls in all age groups and in both genders. HR for death for cases treated with SCs was 1.78 (95% CI 1.49-2.13) and, for cases receiving no treatment, 1.24 (95% CI 1.04-1.48). Sarcoidosis was the most commonly registered cause of death (13.3%).

Conclusion: Patients with sarcoidosis have an increased mortality compared with matched controls. Mortality is particularly high in patients treated with SCs.

Keywords: cohort study; comorbidity; corticosteroid treatment; mortality; population-based; sarcoidosis; therapeutics.

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