Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 12;22(1):21.
doi: 10.1186/s12866-021-02433-6.

The synergistic effect of minocycline and azole antifungal drugs against Scedosporium and Lomentospora species

Fang Yang  1   2 , Yi Sun  3 , Qiaoyun Lu  4
Affiliations

The synergistic effect of minocycline and azole antifungal drugs against Scedosporium and Lomentospora species

Fang Yang et al. BMC Microbiol. .

Abstract

Background: This study was aimed to determine the potency of Minocycline (MIN) and azoles, including itraconazole (ITR), voriconazole (VOR) and posaconazole (POS) against Scedosporium and Lomentospora species.

Results: This study revealed that MIN exhibited no significant antifungal activity against any of the tested strains, whereas in vitro combination of MIN with ITR, VOR or POS showed satisfactory synergistic effects against 8 (80%), 1 (10%), and 9 (90%) strains, respectively. Moreover, combined use of MIN with azoles decreased the minimum inhibitory concentration (MIC) range from 5.33-16 μg/ml to 1-16 μg/ml for ITR, from 0.42-16 μg/ml to 0.21-16 μg/ml for VOR, and from 1.33-16 μg/ml to 0.33-16 μg/ml for POS. Meanwhile, no antagonistic interactions were observed between the above combinations. The G. mellonella infection model demonstrated the in vivo synergistic antifungal effect of MIN and azoles.

Conclusions: The present study demonstrated that combinations between MIN and azoles lead to synergistic antimicrobial effects on Scedosporium and Lomentospora species, while showing a potential for overcoming and preventing azole resistance.

Keywords: Antifungal effect; Azole; Lomentospora; Minocycline; Resistance; Scedosporium; Synergy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Fig. 1
Fig. 1
G. mellonella survival rates
Fig. 2
Fig. 2
G. mellonella histopathology. a Scedosporium Group; b POS Group; c POS + MIN Group; d ITR Group; e ITR + MIN Group; f VOR Group; g VOR + MIN Group; Yellow and blue frame
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O. Invasive fungal infection. Dtsch Arztebl Int. 2019;116(16):271–278. - PMC - PubMed
    1. Sardi JCO, Scorzoni L, Bernardi T, Fusco-Almeida AM, Mendes Giannini MJS. Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol. 2013;62(Pt 1):10–24. doi: 10.1099/jmm.0.045054-0. - DOI - PubMed
    1. Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Azeredo J. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev. 2012;36(2):288–305. doi: 10.1111/j.1574-6976.2011.00278.x. - DOI - PubMed
    1. Cortez KJ, Roilides E, Quiroz-Telles F, Meletiadis J, Antachopoulos C, Knudsen T, et al. Infections caused by Scedosporium spp. Clin Microbiol Rev. 2008;21(1):157–197. doi: 10.1128/CMR.00039-07. - DOI - PMC - PubMed
    1. Bouchara JP, Papon N. Scedosporium apiospermum. Trends Microbiol. 2019;27(12):1045–1046. doi: 10.1016/j.tim.2019.07.003. - DOI - PubMed

Publication types

LinkOut - more resources