Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug;17(8):1745-1747.
doi: 10.4103/1673-5374.332145.

Targeting the epigenome to treat neurodegenerative diseases or delay their onset: a perspective

Fabio Coppede  1
Affiliations

Targeting the epigenome to treat neurodegenerative diseases or delay their onset: a perspective

Fabio Coppede. Neural Regen Res. 2022 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

None

Figures

Figure 1
Figure 1
Potential strategies to prevent or delay neurodegeneration. Epigenetic modifications leading to impaired neuronal function and plasticity can be triggered by early-life environmental factors such as pre- and post-natal dietary restrictions or overfeeding, parental stressful events, and exposure to neurotoxicants. Subsequent harmful environmental exposures, dietary habits and lifestyles within the course of life can further contribute to the neuronal damage, ultimately leading to the onset of neurodegenerative diseases later in life. Our ability to detect as early as possible epigenetic marks of early-life exposure as well as epigenetic biomarkers of increased risk to develop neurodegeneration later in life could represent a challenging opportunity to plan epigenetic interventions with natural compounds, exercise and brain stimulation to enhance neuronal plasticity and prevent or delay neurodegeneration. Particular effort should be put in the search of preclinical epigenetic biomarkers of neurodegeneration, in order to identify older adult subjects that could particularly benefit from those interventions.
See this image and copyright information in PMC

References

    1. Coppedè F. The potential of epigenetic therapies in neurodegenerative diseases. Front Genet. 2014;5:220. - PMC - PubMed
    1. Coppedè F. Epigenetics of neuromuscular disorders. Epigenomics. 2020;12:2125–2139. - PubMed
    1. Coppedè F. Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target. Expert Opin Ther Targets. 2021a;25:283–298. - PubMed
    1. Coppedè F. One-carbon epigenetics and redox biology of neurodegeneration. Free Radic Biol Med. 2021b;170:19–33. - PubMed
    1. Creighton SD, Stefanelli G, Reda A, Zovkic IB. Epigenetic mechanisms of learning and memory: implications for aging. Int J Mol Sci. 2020;21:6918. - PMC - PubMed