doi: 10.1007/BF02014248.
Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892
Affiliations
- PMID: 3501757
- DOI: 10.1007/BF02014248
Item in Clipboard
Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892
Eur J Clin Microbiol.
1987 Oct.
Abstract
A novel 1-carbacephem, LY163892, was determined to be more stable to plasmid-mediated beta-lactamases than cefaclor. Chromosomal-mediated Type Ia and IVc enzymes destroyed LY163892 at rates ranging from 16 to 93% that of nitrocefin. LY163892 showed minimal ability to inhibit beta-lactamases other than Type Ia (P99).
Similar articles
-
In vitro activity and beta-lactamase stability of LY163892.Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):549-51. doi: 10.1007/BF01962613. Eur J Clin Microbiol Infect Dis. 1988. PMID: 3141170
-
In-vitro activity and beta-lactamase stability of LY163892.J Antimicrob Chemother. 1988 Aug;22(2):155-65. doi: 10.1093/jac/22.2.155. J Antimicrob Chemother. 1988. PMID: 3263352
-
Comparative beta-lactamase hydrolysis of and inhibition by 7-aminothiazolyl alpha-methoxyimino cephalosporins.Infection. 1982 Sep-Oct;10(5):303-6. doi: 10.1007/BF01640880. Infection. 1982. PMID: 6293977
-
Comparative in-vitro activity of a new oral carbacephem, LY163892.J Antimicrob Chemother. 1988 Oct;22(4):445-56. doi: 10.1093/jac/22.4.445. J Antimicrob Chemother. 1988. PMID: 3060458
-
Characterization of beta-lactamases.Antimicrob Agents Chemother. 1989 Mar;33(3):259-63. doi: 10.1128/AAC.33.3.259. Antimicrob Agents Chemother. 1989. PMID: 2658779 Free PMC article. Review. No abstract available.
Cited by
-
Comparison of loracarbef (LY163892) versus amoxicillin in the treatment of bronchopneumonia and lobar pneumonia.Infection. 1992 May-Jun;20(3):176-82. doi: 10.1007/BF01704619. Infection. 1992. PMID: 1463527 Clinical Trial.
-
Pharmacokinetics of LY163892 in infants and children.Antimicrob Agents Chemother. 1988 Nov;32(11):1738-9. doi: 10.1128/AAC.32.11.1738. Antimicrob Agents Chemother. 1988. PMID: 3252754 Free PMC article.
-
Loracarbef versus penicillin V in the treatment of streptococcal pharyngitis and tonsillitis.Infection. 1992 Sep-Oct;20(5):301-8. doi: 10.1007/BF01710806. Infection. 1992. PMID: 1428189 Clinical Trial.
-
Susceptibility of new beta-lactams to the expanded-spectrum beta-lactamase CTX-1.Infection. 1989 Jan-Feb;17(1):28-30. doi: 10.1007/BF01643496. Infection. 1989. PMID: 2646226
-
beta-Lactamase stability and in vitro activity of oral cephalosporins against strains possessing well-characterized mechanisms of resistance.Antimicrob Agents Chemother. 1989 Aug;33(8):1313-7. doi: 10.1128/AAC.33.8.1313. Antimicrob Agents Chemother. 1989. PMID: 2802558 Free PMC article.