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. 1987 Oct;6(5):570-1.
doi: 10.1007/BF02014248.

Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892

R N Jones  1 , A L Barry
Affiliations

Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892

R N Jones et al. Eur J Clin Microbiol. 1987 Oct.

Abstract

A novel 1-carbacephem, LY163892, was determined to be more stable to plasmid-mediated beta-lactamases than cefaclor. Chromosomal-mediated Type Ia and IVc enzymes destroyed LY163892 at rates ranging from 16 to 93% that of nitrocefin. LY163892 showed minimal ability to inhibit beta-lactamases other than Type Ia (P99).

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