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. 2022 Jan 4:15:7-13.
doi: 10.2147/DMSO.S335957. eCollection 2022.

Platelet-to-Lymphocyte Ratio Predicts the Presence of Diabetic Neurogenic Bladder

Yiying Liu #  1 , Xin Wang #  2 , Linying Wang  1 , Wenwen Chen  3 , Wenyue Liu  1 , Tingting Ye  1 , Jing Hong  1 , Hong Zhu  1 , Feixia Shen  1
Affiliations

Platelet-to-Lymphocyte Ratio Predicts the Presence of Diabetic Neurogenic Bladder

Yiying Liu et al. Diabetes Metab Syndr Obes. .

Abstract

Purpose: Diabetic neurogenic bladder (DNB) has been widely recognized in recent years. It is common in patients with long-term diabetes and may also lead to many severe complications. Although there has been widespread evidence that inflammation is involved in the development of some diabetic complications, there is little evidence that this can also occur in the bladder. In recent years, platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been viewed as potential novel markers of inflammatory responses. This study was designed to evaluate the relationship between the presence of DNB and the PLR and NLR.

Patients and methods: A total of 371 cases of T2DM patients were included in this retrospective study. Patients were divided into two groups, with 115 diabetic subjects diagnosed with diabetic neurogenic bladder and 256 control subjects without DNB. The independent predictors of DNB were analyzed using logistic regression.

Results: Compared with patients without DNB, the mean PLR and NLR were significantly higher in those with DNB (p < 0.001). Based on the logistic regression, PLR was found to be an independent risk factor for DNB (odds ratio [OR]: 1.408, 95% confidence interval [CI]: 1.248-1.617). From the receiver operating characteristic (ROC) curve, using PLR as indicative of DNB was expected to be 101.1949, and it generated a sensitivity and specificity value of 89.6% and 23.4%, respectively. The area under the curve (AUC) was also found to be 0.899 (95% CI: 0.865-0.932).

Conclusion: In our study, PLR and NLR were significantly higher for patients with DNB. The PLR was found to be a risk factor in the presence of DNB after correcting for possible confounding factors. Considering the severe complications associated with DNB, patients with elevated PLR should be seriously cared for in clinics.

Keywords: diabetic autonomic neuropathy; inflammatory response; neurogenic bladder; oxidative stress.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Logistic forest plot showing independent predictors of DNB.
Figure 2
Figure 2
Receiver-operating characteristics (ROC) curve analysis for platelet-to-lymphocyte ratio as a predictor of the severity of diabetic neurogenic bladder.
See this image and copyright information in PMC

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