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. 2022 Jan 5;34(3):e1618.
doi: 10.1590/0102-672020210002e1618. eCollection 2022.

PROTOCOL FOR LIVER TRANSPLANTATION IN HILAR CHOLANGIOCARCINOMA

[Article in English, Portuguese]
Lucas Ernani  1 , Rodrigo Bronze de Martino  1 , Wellington Andraus  1 , Eduardo de Souza Martins Fernandes  2   3 , Felipe Pedreira Tavares de Mello  2   3 , Ronaldo Andrade  2   3 , Leandro Savattone Pimentel  2   3 , Luciana Bertocco de Paiva Haddad  1 , Fabricio Ferreira Coelho  1 , Paulo Herman  1 , Luiz Augusto Carneiro D'Albuquerque  1
Affiliations

PROTOCOL FOR LIVER TRANSPLANTATION IN HILAR CHOLANGIOCARCINOMA

[Article in English, Portuguese]
Lucas Ernani et al. Arq Bras Cir Dig. .

Abstract
in English, Portuguese

Background: Hilar cholangiocarcinoma represents more than half of all cholangiocarcinoma cases, having poor prognosis and presenting a median overall survival after diagnosis of 12-24 months. In patients who have unresectable tumors with a better prognosis, the proposal to perform liver transplantation emerged for expanding the possibility of free margins by performing total hepatectomy.

Aim: To provide a Brazilian protocol for liver transplantation in patients with hilar cholangiocarcinoma.

Method: The protocol was carried out by two Brazilian institutions which perform a large volume of resections and liver transplantations, based on the study carried out at the Mayo Clinic. The elaboration of the protocol was conducted in four stages.

Result: A protocol proposal for this disease is presented, which needs to be validated for clinical use.

Conclusion: The development of a liver transplantation protocol for cholangiocarcinoma aims not only to standardize the treatment, but also enable a better assessment of the surgical results in the future.

Racional:: O colangiocarcinoma hilar representa mais da metade de todos os casos de colangiocarcinoma; tem prognóstico reservado e sobrevida global mediana de 12- 24 meses após o diagnóstico. A proposta de realizar transplante hepático surgiu para ampliar a possibilidade de margens livres através de hepatectomia total nos portadores de tumoresirressecáveis com melhor prognóstico.

Objetivo:: Apresentar protocolo brasileiro para realização de transplante hepático em pacientes com colangiocarcinoma hilar.

Método:: O protocolo foi realizado por duas instituições com grande volume de ressecções e transplantes hepáticos no Brasil, baseado no trabalho realizado pela MayoClinic. A elaboração foi dividida em quatro etapas.

Resultado:: É apresentada proposta de protocolo para esta doença a ser validada na aplicação clínica.

Conclusão:: Foi possível elaborar protocolo de transplante hepático para colangiocarcinoma a fim de uniformizar o tratamento e melhor avaliar os resultados cirúrgicos.

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Conflict of interest statement

Conflict of interest: none

Figures

FIGURE 1
FIGURE 1. Protocol created by the authors for liver transplantation in hilar cholangiocarcinoma.
FIGURE 2
FIGURE 2. Document of SNT to be filled in to request a special situation for hCCA.
None
Protocol for liver transplantation in hilar cholangiocarcinoma
See this image and copyright information in PMC

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