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Review
. 2022 Feb;14(4):271-288.
doi: 10.4155/fmc-2021-0081. Epub 2022 Jan 12.

Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Daljeet Singh Dhanjal  1 , Parvarish Sharma  2 , Meenu Mehta  3 , Murtaza M Tambuwala  4 , Parteek Prasher  5 , Keshav R Paudel  6 , Gang Liu  6 , Shakti D Shukla  3 , Philip M Hansbro  6 , Dinesh Kumar Chellappan  7 , Kamal Dua  3 , Saurabh Satija  2
Affiliations
Review

Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Daljeet Singh Dhanjal et al. Future Med Chem. 2022 Feb.

Abstract

Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

Keywords: COPD; NDDS; remodeling; respiratory disorders.

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Conflict of interest statement

Financial & competing interests disclosure

PM Hansbro is funded by a fellowship and grants from the National Health and Medical Research Council (NHMRC) of Australia (1175134) and by UTS. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Figures

Figure 1.
Figure 1.. Anatomy of respiratory system and airway epithelium.
Figure 2.
Figure 2.. Different structural changes and inflammation response in the lung (with asthma and chronic obstructive pulmonary disease).
COPD: Chronic obstructive pulmonary disease.
Figure 3.
Figure 3.. Contribution of different types of cells in pathology during airway remodeling in respiratory diseases.
ASM: Airway smooth muscle; ECM: Extracellular matrix.
Figure 4.
Figure 4.. Challenges involved during respiratory drug development.
Figure 5.
Figure 5.. Nanocarriers for drug delivery in the lungs.
NP: Nanoparticle; PLGA: Poly(lactic-co-glycolic acid).
See this image and copyright information in PMC

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