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Comment
. 2022 Feb 1;158(2):200-201.
doi: 10.1001/jamadermatol.2021.5485.

Interventions for Cutaneous Disease in Systemic Lupus Erythematosus: Summary of a Cochrane Review

Grant Sprow  1   2 , Mohsen Afarideh  1   2 , Victoria P Werth  1   2
Affiliations
Comment

Interventions for Cutaneous Disease in Systemic Lupus Erythematosus: Summary of a Cochrane Review

Grant Sprow et al. JAMA Dermatol. .

Abstract

Clinical question: What is the efficacy of interventions for cutaneous disease in systemic lupus erythematosus (SLE) in randomized clinical trials (RCTs)?

Bottom line: Available RCT evidence on the management of cutaneous disease in SLE is sparse and of limited quality. Among traditional options, methotrexate and hydroxychloroquine have the strongest evidence compared with placebo in the end points of complete clinical response and number of clinical flares, respectively, while chloroquine appears noninferior to methotrexate in achieving complete clinical response.

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