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Comment
. 2022 Feb 7;219(2):e20212269.
doi: 10.1084/jem.20212269. Epub 2022 Jan 12.

Goldilocks and the three TILs

Hannah Dada  1 , Michael L Dustin  2
Affiliations
Comment

Goldilocks and the three TILs

Hannah Dada et al. J Exp Med. .

Abstract

In this issue of JEM, Shakiba et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201966) tell a tale of three tumor infiltrating lymphocytes (TILs). The first TIL was too strong and became exhausted. The second TIL was too weak and became inert. The third TIL lost CD8, and this made it just right.

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Figures

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Insights from Hannah Dada and Michael L. Dustin.
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Finding the Goldilocks zone for TILs. (A) Exhausted TILs elicited by strong antigen recognition fail to control MCA205 fibrosarcoma. (B) Weak antigen recognition leads to effector TILs but can’t trigger MCA205 killing. (C) Replication of result in A with B16 melanoma model in the presence of anti-PD1. (D) Loss of CD8 from A resulted in just-right effector TILs that were able to kill B16 in the presence of anti-PD1—the Goldilocks zone.
See this image and copyright information in PMC

Comment on

  • TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.
    Shakiba M, Zumbo P, Espinosa-Carrasco G, Menocal L, Dündar F, Carson SE, Bruno EM, Sanchez-Rivera FJ, Lowe SW, Camara S, Koche RP, Reuter VP, Socci ND, Whitlock B, Tamzalit F, Huse M, Hellmann MD, Wells DK, Defranoux NA, Betel D, Philip M, Schietinger A. Shakiba M, et al. J Exp Med. 2022 Feb 7;219(2):e20201966. doi: 10.1084/jem.20201966. Epub 2021 Dec 22. J Exp Med. 2022. PMID: 34935874 Free PMC article.

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