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. 1987 Sep;6(3):403-7.
doi: 10.1007/BF02206840.

Interleukin-1-production by monocytes from patients with systemic lupus erythematosus

S Sierakowski  1 , E J Kucharz, R W Lightfoot Jr, J S Goodwin
Affiliations

Interleukin-1-production by monocytes from patients with systemic lupus erythematosus

S Sierakowski et al. Clin Rheumatol. 1987 Sep.

Abstract

Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 micrograms of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.

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References

    1. Am J Med. 1973 Jul;55(1):25-31 - PubMed
    1. Clin Exp Immunol. 1986 Apr;64(1):80-7 - PubMed
    1. J Immunol. 1978 May;120(5):1497-503 - PubMed
    1. Clin Immunol Immunopathol. 1984 Aug;32(2):166-73 - PubMed
    1. J Immunol. 1981 Jun;126(6):2321-7 - PubMed

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