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Comment
. 2022 Jan;12(1):23-25.
doi: 10.1158/2159-8290.CD-21-1430.

To Degrade or Not to Degrade DNMT3A

Yuhong Ma  1 , Britta Will  2   3
Affiliations
Comment

To Degrade or Not to Degrade DNMT3A

Yuhong Ma et al. Cancer Discov. 2022 Jan.

Abstract

Aberrant DNA cytosine methylation is a critical contributor to compromised tissue regeneration and malignant transformation, particularly during aging. In this issue of Cancer Discovery, Huang and colleagues define a new class of disease-associated DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) variants with decreased de novo DNA methylation activity due increased proteasomal degradation that are able to drive clonal expansion of hematopoietic stem cells.See related article by Huang et al., p. 220.

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References

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