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Review
. 2021:1339:131-137.
doi: 10.1007/978-3-030-78787-5_18.

Ebola Virus Disease and Current Therapeutic Strategies: A Review

Kalliopi Io Diakou  1 , Thanasis Mitsis  1 , Katerina Pierouli  1 , Eleni Papakonstantinou  1 , Erik Bongcam-Rudloff  2 , Misaki Wayengera  3 , Dimitrios Vlachakis  4   5   6
Affiliations
Review

Ebola Virus Disease and Current Therapeutic Strategies: A Review

Kalliopi Io Diakou et al. Adv Exp Med Biol. 2021.

Abstract

The Ebola virus disease is a severe hemorrhagic fever that affects humans and other primates. Ebola virus, the causative agent of the disease, is transmitted to humans from wild animals and is highly contagious and aggressive with an estimated fatality rate to be around 50%. Since 1976, 11 outbreaks of Ebola virus disease have been reported in total, affecting mostly sub-Saharan Africa, while the most recent ongoing outbreak in the Democratic Republic of the Congo has more than 3000 reported cases and 72 deaths. Although an effective vaccine against Ebola virus disease has become available, no targeted treatment with proven efficacy upon infection is developed. Herein, we review the epidemiology of Ebola virus and the current situation in terms of prevention, diagnosis, and treatment of the disease.

Keywords: Ebola virus; Epidemiology; Infectious disease; Treatment.

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References

    1. Murray MJ (2015) Ebola virus disease: a review of its past and present. Anesth Analg 121(3):798–809. https://doi.org/10.1213/ane.0000000000000866 - DOI - PubMed
    1. Nicastri E, Kobinger G, Vairo F, Montaldo C, Mboera LEG et al (2019) Ebola virus disease: epidemiology, clinical features, management, and prevention. Infect Dis Clin N Am 33(4):953–976. https://doi.org/10.1016/j.idc.2019.08.005 - DOI
    1. Nachega JB, Mbala-Kingebeni P, Otshudiema J, Mobula LM, Preiser W et al (2020) Responding to the challenge of the dual COVID-19 and Ebola epidemics in the Democratic Republic of Congo-priorities for achieving control. Am J Trop Med Hyg. https://doi.org/10.4269/ajtmh.20-0642
    1. Papageorgiou L, Loukatou S, Sofia K, Maroulis D, Vlachakis D (2016) An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targets. Mol BioSyst 12(7):2080–2093. https://doi.org/10.1039/c5mb00706b - DOI - PubMed
    1. Vlachakis D, Koumandou VL, Kossida S (2013) A holistic evolutionary and structural study of flaviviridae provides insights into the function and inhibition of HCV helicase. PeerJ 1:e74. https://doi.org/10.7717/peerj.74 - DOI - PubMed - PMC

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