Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jan 7;23(1):1-16.
doi: 10.1080/14686996.2021.2015249. eCollection 2022.

Self-assisted wound healing using piezoelectric and triboelectric nanogenerators

Fu-Cheng Kao  1   2   3   4 , Hsin-Hsuan Ho  2 , Ping-Yeh Chiu  3   4 , Ming-Kai Hsieh  3   4 , Jen-Chung Liao  3   4 , Po-Liang Lai  3   4 , Yu-Fen Huang  2   5 , Min-Yan Dong  6 , Tsung-Ting Tsai  3   4 , Zong-Hong Lin  1   7   8
Affiliations
Review

Self-assisted wound healing using piezoelectric and triboelectric nanogenerators

Fu-Cheng Kao et al. Sci Technol Adv Mater. .

Abstract

The complex process of wound healing depends on the coordinated interaction between various immunological and biological systems, which can be aided by technology. This present review provides a broad overview of the medical applications of piezoelectric and triboelectric nanogenerators, focusing on their role in the development of wound healing technology. Based on the finding that the damaged epithelial layer of the wound generates an endogenous bioelectric field to regulate the wound healing process, development of technological device for providing an exogenous electric field has therefore been paid attention. Authors of this review focus on the design and application of piezoelectric and triboelectric materials to manufacture self-powered nanogenerators, and conclude with an outlook on the current challenges and future potential in meeting medical needs and commercialization.

Keywords: 201 Electronics / Semiconductor / TCOs < 200 Applications, 202 Dielectrics / Piezoelectrics / Insulators < 200 Applications, 211 Scaffold / Tissue engineering/Drug delivery < 200 Applications, 212 Surface and interfaces < 200 Applications; Wound healing; nanogenerator; piezoelectric effect; self-powered system; triboelectric effect.

PubMed Disclaimer

Conflict of interest statement

No relevant financial or nonfinancial relationships.

Figures

None
Graphical abstract
Figure 1.
Figure 1.
The electric field (EF) generated by the difference in transepithelial potential (TEP) in the damaged epithelial layer regulates the skin-cell behavior and promotes regeneration activity. (Copyright 2003, Elsevier).
Figure 2.
Figure 2.
Four triboelectric nanogenerator (TENG) operational modes: the (a) vertical contact-separation (CS), (b) lateral sliding (LS), (c) single-electrode (SE), and (d) freestanding triboelectric-layer (FT) modes. (Copyright 2018, John Wiley and Sons).
Figure 3.
Figure 3.
(a) PENG skin patch featuring aligned zinc oxide (ZnO) nanorods on polydimethylsiloxane (PDMS) matrix. (b) Enhanced fibroblast growth factor (EGF-2) production and gene expressions of transforming growth factor-β (TGF-β), TGF-β receptor, and collagen type III. (c) Wound healing promoted by ZnO-based piezoelectric patch. (Copyright 2016, John Wiley and Sons).
Figure 4.
Figure 4.
(a) Poly(vinylidene fluoride-tri-fluoroethylene) (P(VDF-TrFE)) nanofiber scaffolds increased fibroblast cell proliferation rate by 1.6 times. (b) In an animal study, the P(VDF-TrFE) nanofiber scaffolds generated a maximum output of 6 mV and ~6 μA through the natural body activity and physiological environment of rats. (Copyright 2018, Elsevier).
Figure 5.
Figure 5.
(a) Polydopamine coated on a chitosan film (CM@DA). (b) Increased wound healing rates were observed for rats in the CM@DA plus near-infrared (NIR) irradiation group. (Copyright 2020, Elsevier).
Figure 6.
Figure 6.
(a) Biomechanical energy conversions of sliding-mode TENG and dressing electrodes of self-activating TENG bandage. (b) The wound closure rate was accelerated in the TENG group. (Copyright 2018, ACS).
Figure 7.
Figure 7.
(a) Structure of rotatory disc-shaped TENG (RD-TENG). (b) In vitro, enhanced fibroblast proliferation and migration were observed with RD-TENG current output of 10–50 μA. (Copyright 2019, Elsevier).
Figure 8.
Figure 8.
(a) Structure and working mechanism of ionic TENG. (b) Significant wound closure to 40% on Day 3 for Gel-TENG. (c) Design of drug-loaded TENG composed of polytetrafluoroethylene (PTFE) and Mg-Al LDH@Al film (LDH: layered double hydroxide) as the electrode and minocycline container, respectively. d) Rapid infected-wound healing process accentuated by antibacterial and electric stimulation efficacy of drug-loaded TENG (MSETENG). (Copyright 2021, Elsevier).
See this image and copyright information in PMC

References

    1. Pollard BD. Principles of Instrumental Analysis (Skoog, D. A.; West, D. M.). Journal of Chemical Education. 1981. Oct 1;58 (10):A314 .
    1. Topolov VY, Bowen CR, Bisegna P. New aspect-ratio effect in three-component composites for piezoelectric sensor, hydrophone and energy-harvesting applications. Sensors Actuators a-Phys. 2015;229:93–104.
    1. Mohammadi MM. A comparison between quartz and PZT ceramic for sensoric applications. Res Desk. 2015;2(4):321–325.
    1. Kim D, Hong S, Hong J, et al. Fabrication of vertically aligned ferroelectric polyvinylidene fluoride mesoscale rod arrays. J Appl Polym Sci. 2013;130(6):3842–3848.
    1. Ramadan KS, Sameoto D, Evoy S. A review of piezoelectric polymers as functional materials for electromechanical transducers. Smart Mater Struct. 2014;23(3):033001.

LinkOut - more resources