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. 2021 Nov 24:11:783635.
doi: 10.3389/fcimb.2021.783635. eCollection 2021.

Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children

Lili Zhou  1 , Yuan Li  1 , Zhufei Xu  2 , Xuyun Peng  1 , Xiaoyan Gong  1 , Lin Yang  1
Affiliations

Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children

Lili Zhou et al. Front Cell Infect Microbiol. .

Abstract

Objective: To investigate the correlation between serum immunoglobulin E (IgE) levels and the complications in children with Mycoplasma pneumoniae pneumonia (MPP).

Methods: A retrospective study of MPP patients hospitalized from May 2019 to July 2021 was performed. We analyzed the clinical manifestations, complications, laboratory findings, and treatments.

Results: A total of 275 patients who met the inclusion criteria were enrolled in the study. We divided patients into two groups based on whether there were complications. Complications occurred in 147 patients, of which pulmonary complications were more common than extrapulmonary complications. The IgE level in the complication group was higher than that in the non-complication group with p = 0.041. Patients with complications of necrotizing pneumonitis, pneumothorax, skin rash, or bronchiolitis obliterans had higher IgE levels. There was no statistically significant difference in IgE levels between pulmonary complications and extrapulmonary complications. The older the age, the greater the probability of complications (p = 0.001). The group with complications was more likely to have chest pain (p = 0.000), while the group without complications was more likely to have wheezing (p = 0.017). The use of bronchoscopy and glucocorticoids was higher in the complication group than in the non-complication group (p = 0.000).

Conclusions: MPP patients with higher IgE levels had more severe clinical symptoms and complications. We speculated that IgE might be a biomarker for complications after MP infection.

Keywords: Children; Immunoglobulin E; Mycoplasma pneumoniae; Severe Mycoplasma pneumoniae pneumonia; complications.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The IgE level in the pulmonary complication group and extrapulmonary complication group.
Figure 2
Figure 2
The IgE level in the complication group and the non-complication group.
Figure 3
Figure 3
The value on the receiver operating characteristic (ROC) curve of the IgE level between the complication group and the non-complication group.
See this image and copyright information in PMC

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