Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 11:18:100331.
doi: 10.1016/j.lanwpc.2021.100331. eCollection 2022 Jan.

Epidemiology of Moyamoya disease in China: A nationwide hospital-based study

Dong Zhang  1   2   3 , Liangran Huang  1   2   3 , Zheng Huang  4 , Qi Zhou  1   2 , Xin Yang  1   2 , Hongqiu Gu  1   2 , Zixiao Li  1   2   5 , Ying Shi  6 , Lanxia Gan  6 , Haibo Wang  7 , Xvdong Ma  2 , Yongjun Wang  1   2   5 , Jizong Zhao  1   3
Affiliations

Epidemiology of Moyamoya disease in China: A nationwide hospital-based study

Dong Zhang et al. Lancet Reg Health West Pac. .

Abstract

Background: The national epidemiologic data in mainland China is still absent for moyamoya disease (MMD).

Methods: This study was a nationwide hospital-based observational retrospective study to estimate epidemiological characteristics of MMD. The data was based on the Hospital Quality Monitoring System (HQMS), a national database which covers all tertiary hospitals in mainland China. This system consistently collects medical records including demographic characteristics, diagnoses, procedures, and expenses etc. for all inpatients. MMD was identified by ICD-10 code (I67·5) in HQMS.

Findings: A total of 47,443 new-onset patients with total 69,680 hospitalization records from 1312 hospitals during 2016 to 2018 were included. The annual incidence rate was 1·14 per 100,000 inhabitants (95% CI, 1·12-1·16) and approximately a 2-fold increase from 2016 to 2018. The incidence in children (0·18 per 100,000 inhabitants per year; 95% CI, 0·17-0·20) was significantly lower than that in adults (1·40 per 100,000; 95% CI, 1·38-1·42) (P<0·001) and the peak incidence was 45-54 years. The distribution model of incidence rate was presented as a clustered regional pattern (Moran's I = 0·155, P = 0·018, Z = 2·375) by global spatial correlation analysis.

Interpretation: Our study reported the annual incidence of MMD was 1·14 per 100,000 inhabitants in mainland China during 2016 to 2018, and it was increasing year by year. The geographical distribution of MMD incidence presented as a clustered regional pattern, which may provide new view for future study on the etiology for MMD.

Funding: National Natural Science Foundation of China and "13th Five-Year Plan" National Science and Technology Supporting Plan.

Keywords: Epidemiology; Geographical distribution; Incidence; Moyamoya disease.

PubMed Disclaimer

Conflict of interest statement

We declare no competing interests.

Figures

Fig 1
Fig. 1
Flowchart of study population selection.
Fig 2
Fig. 2
Incidence map of moyamoya disease in mainland China during 2016 to 2018. The study was conducted in mainland China. Hong Kong, Macao, and Taiwan were not included. Major rivers in mainland China are also shown in the figure.
Fig 3
Fig. 3
The incidence of moyamoya disease in different age groups during 2016 to 2018.
Fig 4
Fig. 4
Clinical presentations in patients with moyamoya disease according to age.
See this image and copyright information in PMC

References

    1. Smith Scott R.M., Smith E.R. Moyamoya disease and moyamoya syndrome. N Engl J Med. 2009;360:1226–1237. - PubMed
    1. Kuroda S., Houkin K. Moyamoya disease: current concepts and future perspectives. Lancet Neurol. 2008;(7):1056–1066. - PubMed
    1. Wakai K., Tamakoshi A., Ikezaki K., et al. Epidemiological features of moyamoya disease in Japan: findings from a nationwide survey. Clin Neurol Neurosurg. 1997;99(Suppl 2):S1–S5. - PubMed
    1. Kuriyama S., Kusaka Y., Fujimura M., et al. Prevalence and clinicoepidemiological features of moyamoya disease in Japan: findings from a nationwide epidemiological survey. Stroke. 2008;39(1):42–47. - PubMed
    1. Baba T., Houkin K., Kuroda S. Novel epidemiological features of moyamoya disease. J Neurol Neurosurg Psychiatry. 2008;79(8):900–904. - PubMed

LinkOut - more resources