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. 2021 Apr-Jun;62(2):605-613.
doi: 10.47162/RJME.62.2.30.

Conventional grade 1 chondrosarcoma: a challenging diagnosis with important implications on therapy and prognosis

Gabriel Veniamin Cozma  1 , Laurenţiu Vasile Sima, Raluca Maria Cloşca, Flavia Baderca, Ioana Delia Horhat, Nicolae Constantin Balica, Alina Andreea Tischer, Ion Cristian Moţ, Daniel Claudiu Maliţa, Aurel Marin, Cristian Andrei Sarău
Affiliations

Conventional grade 1 chondrosarcoma: a challenging diagnosis with important implications on therapy and prognosis

Gabriel Veniamin Cozma et al. Rom J Morphol Embryol. 2021 Apr-Jun.

Abstract

Chondrosarcoma (CHS) is a malignant tumor of soft tissue with cartilaginous differentiation that represent one tenth of all malignant proliferations developed from bone tissues. Even if CHS represents the third malignancy with bone localization, after myeloma and osteosarcoma, it is far less diagnosed in the head and neck region. The current paper presented two cases of conventional CHSs, which were diagnosed in Department of Thoracic Surgery and Department of Otorhinolaryngology of Emergency City Hospital, Timişoara, Romania, between February and June 2021. The malignant cases were of peripheral CHSs, one of scapula, and the other one had an extremely rare tracheal location with microscopic features of conventional low-grade tumors (grade 1). In all cases, conservative surgical curative treatment was performed, with a favorable postoperative evolution.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

Figure 1
Figure 1
Binucleated chondrocytes in cartilaginous matrix. HE staining, ×400. HE: Hematoxylin–Eosin
Figure 2
Figure 2
Atypical chondrocytes with intracytoplasmic inclusions. PAS reaction, ×200. PAS: Periodic Acid–Schiff
Figure 3
Figure 3
Most of the tumor chondrocytes were immunohistochemically positive for S100 protein, ×200
Figure 4
Figure 4
Atypical chondroblast in mitosis, immunohistochemically positive for S100 protein, ×100
Figure 5
Figure 5
Tumor area showing negative immunohistochemical reaction for S100 protein, ×100
Figure 6
Figure 6
Lobules of malignant chondrocytes, with negative immunohistochemical reaction for S100 protein, ×50
Figure 7
Figure 7
Tumor area showing negative immunohistochemical reaction for E-cadherin, ×200
Figure 8
Figure 8
Lobules of malignant chondrocytes, with negative immunohistochemical reaction for p53, ×400
Figure 9
Figure 9
Tumor area showing negative immunohistochemical reaction for Ki67, ×400
Figure 10
Figure 10
Lobules of malignant chondrocytes, with positive immunohistochemical reaction for Ki67, ×200
Figure 11
Figure 11
Atypical chondrocytes, some of them binucleated. HE staining, ×400
Figure 12
Figure 12
The tumor infiltrated the seromucous acini. HE staining, ×100
Figure 13
Figure 13
Respiratory mucosa lined by pseudostratified columnar epithelium disorganized by the tumor. HE staining, ×50
Figure 14
Figure 14
Area of mature squamous metaplasia disrupted by the tumor. HE staining, ×100
Figure 15
Figure 15
Atypical chondrocytes with intracytoplasmic inclusions, in a myxoid stroma. HE staining, ×200
Figure 16
Figure 16
Atypical chondrocytes with intracytoplasmic inclusions. HE staining, ×400
Figure 17
Figure 17
Atypical chondrocytes with intracytoplasmic inclusions. PAS reaction, ×200
Figure 18
Figure 18
Atypical chondrocytes with intracytoplasmic inclusions, invading the lining epithelium. PAS reaction, ×200
Figure 19
Figure 19
Atypical chondrocytes invaded ossified cartilage. HE staining, ×100
Figure 20
Figure 20
The tumor showed areas of osseous metaplasia. HE staining, ×100
Figure 21
Figure 21
Atypical chondrocytes immunohistochemically positive for S100 protein, ×50
Figure 22
Figure 22
The negative immunohistochemical reaction for p53, ×200
Figure 23
Figure 23
The negative immunohistochemical reaction for E-cadherin, ×50
Figure 24
Figure 24
Ki67 index in atypical cells, ×200
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