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Editorial
. 2022 Jan 13;139(2):159-160.
doi: 10.1182/blood.2021013440.

Mitochondria shape neutrophils during hypoxia

Mariana J Kaplan  1
Affiliations
Editorial

Mitochondria shape neutrophils during hypoxia

Mariana J Kaplan. Blood. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Mitochondria play important role in modulating metabolic responses of neutrophils during hypoxia. During hypoxic conditions, neutrophils synthesize enhanced mROS formation, which stabilizes HIF-1α, a transcriptional regulator that promotes oxygen delivery to hypoxic regions. This process relies on the G-3-P shuttle pathway. Modulation of glycolysis leading to increased flux through the G-3-P shuttle promotes enhanced mitochondrial membrane potential and mROS release during hypoxia. GPD2, the mitochondrial component of the G-3-P shuttle, is involved in promoting mROS synthesis, HIF-1α stabilization, and neutrophil survival during hypoxia. Professional illustration by Patrick Lane, ScEYEnce Studios.
See this image and copyright information in PMC

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References

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