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Comment
. 2022 Jan 12;30(1):10-12.
doi: 10.1016/j.chom.2021.12.014.

Microbial Cgr2 will let your Th17 cells ROR(γT)

Naomi Rodriguez-Marino  1 , Luisa Cervantes-Barragan  2
Affiliations
Free article
Comment

Microbial Cgr2 will let your Th17 cells ROR(γT)

Naomi Rodriguez-Marino et al. Cell Host Microbe. .
Free article

Abstract

In this issue of Cell Host & Microbe, Alexander et al. show that the enzyme cardiac glycoside reductase 2 (cgr2), which is produced by Eggerthella lenta, metabolizes RORγT inhibitors, resulting in an increased Th17 response and more severe inflammation in colitis models. The effect of cgr2 can be neutralized by a diet rich in arginine.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Human gut bacterial metabolism drives Th17 activation and colitis.
    Alexander M, Ang QY, Nayak RR, Bustion AE, Sandy M, Zhang B, Upadhyay V, Pollard KS, Lynch SV, Turnbaugh PJ. Alexander M, et al. Cell Host Microbe. 2022 Jan 12;30(1):17-30.e9. doi: 10.1016/j.chom.2021.11.001. Epub 2021 Nov 24. Cell Host Microbe. 2022. PMID: 34822777 Free PMC article.

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