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Comment
. 2022 Jan 13;7(1):16.
doi: 10.1038/s41392-022-00876-5.

Signals from the interface: protein nanoclusters stabilize biomolecular condensates

Christian Hoffmann  1 , Branislava Rankovic  1 , Dragomir Milovanovic  2
Affiliations
Comment

Signals from the interface: protein nanoclusters stabilize biomolecular condensates

Christian Hoffmann et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
MEG-3 nanoclusters as Pickering agents stabilizing PGL granules. a MEG-3 nanoclusters assemble at the surface of PGL-3 condensates and prevent them from coarsening. b In the absence of MEG-3, MBK-2/DYRK3 kinase dissolves PGL condensates. c MEG-3 nanoclusters act as molecular beacons in developing embryos of C. elegans (top), recruiting MBK-2/DYRK3 kinase, thereby allowing for PGL diffusion in and out of granules. In the absence of MEG-3 stabilization (bottom), MBK-2/DYRK3 completely dissolves PGL-3 condensates
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References

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