Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;17(1):528-534.
doi: 10.1016/j.jds.2021.06.023. Epub 2021 Aug 5.

Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study

Estella Musacchio  1 , Pierluigi Binotto  2 , Fatima Silva-Netto  1 , Egle Perissinotto  3 , Leonardo Sartori  1
Affiliations

Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study

Estella Musacchio et al. J Dent Sci. 2022 Jan.

Abstract

Background/purpose: Genetics plays a role in the susceptibility to periodontitis and tooth loss. Several studies examined the involvement of polymorphisms in candidate genes. We hypothesize that bone metabolism-related polymorphisms could be associated with the number of remaining teeth.

Materials and methods: Participants in the Pro.V.A. longitudinal Study: 3099 Italians (aged 65+ at baseline), 2196 at follow-up 1 (5yrs), 1641 at follow-up 2 (7yrs) underwent detailed interview and clinical-instrumental examination. Subjects, grouped by remaining teeth number (0, 1-7, 8-19, 20+), were genotyped for six different bone-related polymorphisms: collagen type Iα1 (COL1A1, Sp1, Ss alleles, n = 1068), vitamin D receptor (VDR, Fok I, Ff alleles, n = 300), calcitonin receptor (CALCR, Alu I, CT alleles, n = 1430), estrogen receptor alpha (ESR1, Pvu II and Xba I, Pp and Xx alleles, n = 1335 and n = 1324).

Results: COL1A1 associated with dental status: ss carriers had reduced incident tooth loss (p < 0.05). The low frequency of this genotype, 3.6% in the whole population, didn't grant sufficient statistical power to other findings, such as the lower prevalence of edentulism, consistent throughout the study. In men, CC genotype of CALCR was associated with higher tooth loss between follow ups (p < 0.05). Biochemical markers of inflammation didn't differ by genotype. Confounders such as diabetes, neoplasms, and smoking hampered the detrimental effect of S allele in the logistic regression analysis (OR = 0.67, 95% CI 0.4-1.0, p = 0.06).

Conclusion: The present study, demonstrating an association between tooth loss and COL1A1 and -in men- CALCR, contributes to the identification of genes involved in tooth loss and, possibly, susceptibility to periodontitis.

Keywords: Bone; Genetic polymorphisms; Oral health; Tooth loss; Type I collagen.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Prevalence of subjects by tooth class and genetic polymorphisms at baseline and follow ups. Panel A: COL1A1 (collagen type Iα1); Panel B: CALCR (calcitonin receptor); Panel C: VDR (vitamin D receptor); Panel D: ESR1-Xba (estrogen receptor alpha). ∗p < 0.02formula image
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. WHO . Vol. 47. 1994. Oral Health. World Health Stat Q; pp. 42–94.http://www.who.int/mediacentre/factsheets/fs318/en/ WHO 2012.
    1. Total tooth loss among persons aged > or =65 years--selected states, 1995-1997. MMWR Morb Mortal Wkly Rep. 1999;48:206–210. - PubMed
    1. Musacchio E., Perissinotto E., Binotto P., et al. Tooth loss in the elderly and its association with nutritional status, socio-economical and lifestyle factors. Acta Odontol Scand. 2007;65:78–86. - PubMed
    1. Reich E., Hiller K.A. Reasons for tooth extraction in the western states of Germany. Community Dent Oral Epidemiol. 1993;21:379–383. - PubMed
    1. Cahen P.M., Frank R.M., Turlot J.C. A survey of the reasons for dental extractions in France. J Dent Res. 1985;64:1087–1093. - PubMed

LinkOut - more resources