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Case Reports
. 2021 Jul 31;7(5Part B):835-837.
doi: 10.1016/j.ijwd.2021.07.011. eCollection 2021 Dec.

Cellular neurothekeoma

Thomas Stewart  1 , Adrian Cachia  2 , John Frew  3   4
Affiliations
Case Reports

Cellular neurothekeoma

Thomas Stewart et al. Int J Womens Dermatol. .
No abstract available

Keywords: Case report; Cellular neurothekeoma; Nerve sheath tumor.

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Conflict of interest statement

Mr John Frew has conducted advisory work for Janssen, Boehringer-Ingelheim, Pfizer, Kyowa Kirin, LEO Pharms, Regeneron, and UCB; participated in trials for UCB, Pfizer, and Eli Lilly; and received research support from Ortho Dermatologics.

Figures

Fig 1
Fig. 1
(A) Clinical presentation: an ill-defined violaceous nodule with peripheral palpable extensions inferior to the right anterior knee. (B) Lobulated dermal neoplasm; arrow corresponds to area of high power cellular detail in Figure 2 (hematoxylin and eosin stain; original magnification × 20).
Fig 2
Fig. 2
(A) Tumor cell detail. Dominant mononuclear population has fine, open chromatin pattern with small but frequently multiple nucleoli (short arrow), with interspersed multinucleate giant cells (long arrow; hematoxylin and eosin stain; original magnification × 400). (B) Immunohistochemical staining for NKI-C3 demonstrating positive staining, supporting the diagnosis of cellular neurothekeoma.
See this image and copyright information in PMC

References

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    1. Hornick JL, Fletcher CD. Cellular neurothekeoma: Detailed characterization in a series of 133 cases. Am J Surg Pathol. 2007;31(3):329–340. - PubMed
    1. Laskin WB, Fetsch JF, Miettinen M. The "neurothekeoma": Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics. Hum Pathol. 2000;31(10):1230–1241. - PubMed
    1. Stratton J, Billings SD. Cellular neurothekeoma: Analysis of 37 cases emphasizing atypical histologic features. Mod Pathol. 2014;27(5):701–710. - PubMed
    1. Zenner K, Dahl J, Deutsch G, Rudzinski E, Bly R, Perkins JA. Metastatic cellular neurothekeoma in childhood. Int J Pediatr Otorhinolaryngol. 2019;119:86–88. - PMC - PubMed

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