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Comment
. 2021 Dec 21;2(12):100479.
doi: 10.1016/j.xcrm.2021.100479.

Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition

Irene Chernova  1 , Joe Craft  2   3
Affiliations
Comment

Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition

Irene Chernova et al. Cell Rep Med. .

Abstract

Antibody deposition is a defining pathological feature of multiple kidney diseases including lupus nephritis. In this issue of Cell Reports Medicine, Jiang and colleagues1 identify a novel genetic risk factor, VANGL1, which predisposes individuals toward antibody deposition via a kidney-intrinsic mechanism.

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Conflict of interest statement

The authors declare no competing interests.

Comment on

  • Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease.
    Jiang SH, Mercan S, Papa I, Moldovan M, Walters GD, Koina M, Fadia M, Stanley M, Lea-Henry T, Cook A, Ellyard J, McMorran B, Sundaram M, Thomson R, Canete PF, Hoy W, Hutton H, Srivastava M, McKeon K, de la Rúa Figueroa I, Cervera R, Faria R, D'Alfonso S, Gatto M, Athanasopoulos V, Field M, Mathews J, Cho E, Andrews TD, Kitching AR, Cook MC, Riquelme MA, Bahlo M, Vinuesa CG. Jiang SH, et al. Cell Rep Med. 2021 Dec 21;2(12):100475. doi: 10.1016/j.xcrm.2021.100475. eCollection 2021 Dec 21. Cell Rep Med. 2021. PMID: 35028616 Free PMC article.

References

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