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Comment
. 2021 Dec 21;2(12):100483.
doi: 10.1016/j.xcrm.2021.100483.

High fat stems tumor immune surveillance

Roberta Caruso  1 , Grace Y Chen  2
Affiliations
Comment

High fat stems tumor immune surveillance

Roberta Caruso et al. Cell Rep Med. .

Abstract

In a recent issue of Cell Stem Cell, Beyaz et al. show that high-fat diets promote tumorigenesis by reducing major histocompatibility complex (MHC) class II expression in intestinal stem cells. Dietary modulation of epithelial MHC II expression is regulated by the gut microbiota.

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Figures

Figure 1
Figure 1
HFD and dysbiosis promote intestinal tumorigenesis The presence of Helicobacter and Odoribacter is associated with increased ISC expression of MHC class II mediated in part by NOD2, TLR2, and IFNγ, which promotes immune surveillance. In the presence of dysbiosis and/or chronic ingestion of HFDs, there is reduced expression of NOD2, TLR2, and IFNγ, and ISC MHC class II associated with decreased abundance of Helicobacter and Odoribacter, resulting in reduced anti-tumor immunity. In addition, HFDs upregulate PPARδ signaling, which leads to ISC expansion and tumorigenesis. Bacteria associated with dysbiosis can also contribute to tumorigenesis by promoting DNA damage and oncogenic activation of Wnt/β-catenin signaling.
See this image and copyright information in PMC

Comment on

  • Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.
    Beyaz S, Chung C, Mou H, Bauer-Rowe KE, Xifaras ME, Ergin I, Dohnalova L, Biton M, Shekhar K, Eskiocak O, Papciak K, Ozler K, Almeqdadi M, Yueh B, Fein M, Annamalai D, Valle-Encinas E, Erdemir A, Dogum K, Shah V, Alici-Garipcan A, Meyer HV, Özata DM, Elinav E, Kucukural A, Kumar P, McAleer JP, Fox JG, Thaiss CA, Regev A, Roper J, Orkin SH, Yilmaz ÖH. Beyaz S, et al. Cell Stem Cell. 2021 Nov 4;28(11):1922-1935.e5. doi: 10.1016/j.stem.2021.08.007. Epub 2021 Sep 15. Cell Stem Cell. 2021. PMID: 34529935 Free PMC article.

References

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