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Comment
. 2021 Dec 21;2(12):100484.
doi: 10.1016/j.xcrm.2021.100484.

Caught in a trap: How pre-clinical studies in laboratory mice exaggerate vaccine responses

Lynda Coughlan  1
Affiliations
Comment

Caught in a trap: How pre-clinical studies in laboratory mice exaggerate vaccine responses

Lynda Coughlan. Cell Rep Med. .

Abstract

In a recent issue of Cell Host and Microbe, Fiege and colleagues1 report that laboratory mice exposed to pathogens from pet-store mice exhibit impaired humoral immunity to influenza vaccination and display gene expression signatures that more authentically reflect human vaccine responses.

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Conflict of interest statement

The author declares no competing interests.

Figures

Figure 1
Figure 1
Pathogen-exposure affects vaccine immunogenicity and efficacy in mice (A) SPF “clean” mice or “dirty” SPF mice exposed to murine pathogens following co-housing with pet-store mice. (B) Immunization of clean mice resulted in higher titers of neutralizing antibodies and IgG subclass antibodies than dirty mice. (C) Improved humoral immunogenicity results in increased protection from influenza challenge than dirty mice. SPF, specific-pathogen free; LAIV, live attenuated influenza vaccine; IIV, inactivated influenza vaccine; OD, optical density. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

References

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