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. 2022 Apr 1;117(4):647-653.
doi: 10.14309/ajg.0000000000001621.

Full-Thickness Scar Resection After R1/Rx Excised T1 Colorectal Cancers as an Alternative to Completion Surgery

Kim M Gijsbers  1   2 , Miangela M Laclé  3 , Sjoerd G Elias  4 , Yara Backes  1 , Joukje H Bosman  5 , Annemarie M van Berkel  6 , Femke Boersma  7 , Jurjen J Boonstra  8 , Philip R Bos  9 , Patty A T Dekker  10 , Paul D Didden  1 , Joost M J Geesing  11 , John N Groen  12 , Krijn J C Haasnoot  1 , Koen Kessels  13 , Anja U G van Lent  14 , Lisa van der Schee  1 , Ruud W M Schrauwen  15 , Ramon-Michel Schreuder  16 , Matthijs P Schwartz  17 , Tom J Seerden  18 , Marcel B W M Spanier  19 , Jochim S Terhaar Sive Droste  20 , Jurriaan B Tuynman  21 , Wouter H de Vos Tot Nederveen Cappel  22 , Erik H L van Westreenen  23 , Frank H J Wolfhagen  24 , Frank P Vleggaar  1 , Frank Ter Borg  2 , Leon M G Moons  1 ; Dutch T1 CRC Working Group
Affiliations

Full-Thickness Scar Resection After R1/Rx Excised T1 Colorectal Cancers as an Alternative to Completion Surgery

Kim M Gijsbers et al. Am J Gastroenterol. .

Abstract

Introduction: Local full-thickness resections of the scar (FTRS) after local excision of a T1 colorectal cancer (CRC) with uncertain resection margins is proposed as an alternative strategy to completion surgery (CS), provided that no local intramural residual cancer (LIRC) is found. However, a comparison on long-term oncological outcome between both strategies is missing.

Methods: A large cohort of patients with consecutive T1 CRC between 2000 and 2017 was used. Patients were selected if they underwent a macroscopically complete local excision of a T1 CRC but positive or unassessable (R1/Rx) resection margins at histology and without lymphovascular invasion or poor differentiation. Patients treated with CS or FTRS were compared on the presence of CRC recurrence, a 5-year overall survival, disease-free survival, and metastasis-free survival.

Results: Of 3,697 patients with a T1 CRC, 434 met the inclusion criteria (mean age 66 years, 61% men). Three hundred thirty-four patients underwent CS, and 100 patients underwent FTRS. The median follow-up period was 64 months. CRC recurrence was seen in 7 patients who underwent CS (2.2%, 95% CI 0.9%-4.6%) and in 8 patients who underwent FTRS (9.0%, 95% CI 3.9%-17.7%). Disease-free survival was lower in FTRS strategy (96.8% vs 89.9%, P = 0.019), but 5 of the 8 FTRS recurrences could be treated with salvage surgery. The metastasis-free survival (CS 96.8% vs FTRS 92.1%, P = 0.10) and overall survival (CS 95.6% vs FTRS 94.4%, P = 0.55) did not differ significantly between both strategies.

Discussion: FTRS after local excision of a T1 CRC with R1/Rx resection margins as a sole risk factor, followed by surveillance and salvage surgery in case of CRC recurrence, could be a valid alternative strategy to CS.

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References

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