doi: 10.1021/acs.jnatprod.1c00878.
Epub 2022 Jan 14.
Anti-inflammatory Dimeric Tetrahydroxanthones from an Endophytic Muyocopron laterale
Affiliations
- PMID: 35029398
- DOI: 10.1021/acs.jnatprod.1c00878
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Anti-inflammatory Dimeric Tetrahydroxanthones from an Endophytic Muyocopron laterale
J Nat Prod.
.
Abstract
Twelve new dimeric tetrahydroxanthones, muyocoxanthones A-L (1-12), were isolated from the endophytic fungus, Muyocopron laterale. Their structures were characterized on the basis of the interpretation of NMR and HRESIMS data. The absolute configurations of 1-10 and 12 were unambiguously determined by ECD spectrum data and single-crystal X-ray diffraction analysis. Compounds 2, 6, and 11 showed inhibitory activity against the LPS-induced production of nitric oxide (NO) in RAW 264.7 cells with IC50 values of 5.2, 1.3, and 5.1 μM, respectively.