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. 2019 Jul 15;2(7):2802-2811.
doi: 10.1021/acsabm.9b00226. Epub 2019 Jun 20.

Exploring Anticancer and (Bio)catalytic Activities of New Oxovanadium(V), Dioxomolybdenum(VI), and Copper(II) Complexes of Amide-Imine Conjugates

Sabyasachi Ta, Milan Ghosh, Kajari Ghosh, Paula Brandão  1 , Vítor Félix  1 , Sumit Kumar Hira, Partha Pratim Manna  2 , Debasis Das
Affiliations

Exploring Anticancer and (Bio)catalytic Activities of New Oxovanadium(V), Dioxomolybdenum(VI), and Copper(II) Complexes of Amide-Imine Conjugates

Sabyasachi Ta et al. ACS Appl Bio Mater. .

Abstract

An amide-imine conjugate, (E)-N'-((2-hydroxynaphthalen-1-yl) methylene)-4-methylbenzohydrazide (PTANAP), derived from 4-methyl-benzoic acid hydrazide (PTA) and 2-hydroxynapthaldehyde, is explored to prepare dinuclear oxovanadium(V), mononuclear dioxomolydenum(VI), and Cu(II) complexes. Single crystal X-ray structurally characterized complexes have been exploited as catalyst for oxidation of ethylbenzene, catechol, and o-aminophenol. The anticancer properties of the oxo-vanadium complex have been explored against human leukemia cell (K-562) and mouse lymphoma cells (2PK3).

Keywords: (bio)catalysis; Cu(II) complex; amide−imine conjugate; anticancer activity; dioxomolybdenum; oxovanadium(V).

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