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Observational Study
. 2022 Jan 14;12(1):729.
doi: 10.1038/s41598-021-04316-2.

Survival, treatment regimens and medical costs of women newly diagnosed with metastatic triple-negative breast cancer

Ju-Yi Hsu  1   2 , Chee-Jen Chang  1   3   4   5   6 , Jur-Shan Cheng  7   8   9
Affiliations
Observational Study

Survival, treatment regimens and medical costs of women newly diagnosed with metastatic triple-negative breast cancer

Ju-Yi Hsu et al. Sci Rep. .

Abstract

Individuals diagnosed with metastatic triple-negative breast cancer (mTNBC) suffer worse survival rates than their metastatic non-TNBC counterparts. There is little information on survival, treatment patterns, and medical costs of mTNBC patients in Asia. Therefore, this study aimed to examine 5-year survival, regimens of first-line systemic therapy, and healthcare costs of mTNBC patients in Taiwan. Adult females newly diagnosed with TNBC and non-TNBC as well as their survival data, treatment regimens and costs of health services were identified and retrieved from the Cancer Registry database, Death Registry database, and National Health Insurance (NHI) claims database. A total of 9691 (19.27%) women were identified as TNBC among overall BC. The 5-year overall survival rate of TNBC and non-TNBC was 81.28% and 86.50%, respectively, and that of mTNBC and metastatic non-TNBC was 10.81% and 33.46%, respectively. The majority of mTNBC patients received combination therapy as their first-line treatment (78.14%). The 5-year total cost in patients with metastatic non-TNBC and with mTNBC was NTD1,808,693 and NTD803,445, respectively. Higher CCI scores were associated with an increased risk of death and lower probability of receiving combination chemotherapy. Older age was associated with lower 5-year medical costs. In sum, mTNBC patients suffered from poorer survival and incurred lower medical costs than their metastatic non-TNBC counterparts. Future research will be needed when there are more treatment options available for mTNBC patients.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Overall survival of TNBC vs. non-TNBC patients by stage: (A) overall; (B) stage I; (C) stage II; (D) stage III; (E) stage IV.
Figure 2
Figure 2
Overall Survival of MBC: (A) non-TNBC by age; (B) TNBC by age; (C) non-TNBC by lymph node status; (D) TNBC by lymph node status.
Figure 3
Figure 3
Mean medical cost per patient per year after diagnosis with metastatic non-TNBC or mTNBC.
See this image and copyright information in PMC

References

    1. Bauer KR, et al. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California cancer Registry. Cancer. 2007;109(9):1721–1728. doi: 10.1002/cncr.22618. - DOI - PubMed
    1. Sorlie T, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001;98(19):10869–10874. doi: 10.1073/pnas.191367098. - DOI - PMC - PubMed
    1. Baser O, et al. Patient survival and healthcare utilization costs after diagnosis of triple-negative breast cancer in a United States managed care cancer registry. Curr Med Res Opin. 2012;28(3):419–428. doi: 10.1185/03007995.2011.628649. - DOI - PubMed
    1. Foulkes WD, Smith IE, Reis-Filho JS. Triple-negative breast cancer. N. Engl. J. Med. 2010;363(20):1938–1948. doi: 10.1056/NEJMra1001389. - DOI - PubMed
    1. Dent R, et al. Pattern of metastatic spread in triple-negative breast cancer. Breast Cancer Res. Treat. 2009;115(2):423–428. doi: 10.1007/s10549-008-0086-2. - DOI - PubMed

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