Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 30;42(3):47-55.
doi: 10.2478/prilozi-2021-0034.

Peritoneal Dialysis-Related Peritonitis: Rate, Clinical Outcomes and Patient Survival

Pavlina Dzekova-Vidimliski  1 , Igor G Nikolov  1 , Nikola Gjorgjievski  1 , Gjulsen Selim  1 , Lada Trajceska  1 , Ana Stojanoska  1 , Irena Rambabova-Bushljetik  1 , Risto Simeonov  2 , Ljupco Stojkovski  2
Affiliations

Peritoneal Dialysis-Related Peritonitis: Rate, Clinical Outcomes and Patient Survival

Pavlina Dzekova-Vidimliski et al. Pril (Makedon Akad Nauk Umet Odd Med Nauki). .

Abstract

Peritoneal dialysis-related peritonitis remains the major complication and primary challenge to the long-term success of peritoneal dialysis (PD). The study aimed to analyze the peritonitis rate, the cause, the outcomes, and the association of peritonitis with the survival of patients on peritoneal dialysis. Patient data were collected retrospectively from medical charts. A total of 96 patients received peritoneal dialysis in the PD center from 1 January 1999 to 31 December 2018. Episodes of peritonitis (n=159) were registered in 54 (56.3%) patients. The study population was divided into two groups, a group of patients (n=54) who experienced peritonitis and a group of patients free of peritonitis (n=42). The peritonitis rate was 0.47 episodes per patient year. The majority of causative microorganisms were gram-positive bacteria (53.5%). Outcomes of the episodes of peritonitis were resolved infection in 84.9% of episodes, catheter removal in 11.3% of episodes, and death in 3.8% of the episodes of peritonitis. A Kaplan-Meier analysis and log-rank test revealed that the group with peritonitis tended to survive significantly longer than the peritonitis-free group. A 67% reduction rate in the risk of patient mortality was observed for the peritonitis group compared with the peritonitis-free group (hazard ratio: 0.33, 95% CI 0.19-0.57, P=0.000). The prevention and management of PD-related infections, resulted in their worldwide reduction, supporting the use of PD as a first-line dialysis modality.

Keywords: bacteria; infection; peritoneal dialysis; peritonitis; survival.

PubMed Disclaimer

References

    1. 1. Abecassis M, Bartlett ST, Collins AJ, et al. Kid-Hu S, Ming P, Qureshi AR, Lindholm B, Bo Y, Yang H. Peritonitis: Episode Sequence, Microbiological Variation, Risk Factors and Clinical Outcomes in a North China Peritoneal Dialysis Center. Kidney Blood Press Res. 2018; 43(5): 1573–84.10.1159/000494443
    1. 2. Grassmann A, Gioberges S, Moeller S, Brown G. ESRD patients in 2004: global overview of patient numbers, treatment modalities and associated trends. Nephrol Dial Transplant. 2005; 20: 2587–9310.1093/ndt/gfi159
    1. 3. Li PK, Chow KM, Van de Luijtgaarden MW, Johnson DW, Jager KJ, Mehrotra R, et al. Changes in the worldwide epidemiology of peritoneal dialysis. Nat Rev Nephrol. 2017 Feb; 13(2): 90–103.10.1038/nrneph.2016.181
    1. 4. Cho Y, Johnson DW. Peritoneal dialysis-related peritonitis: towards improving evidence, practices, and outcomes. Am J Kidney Dis. 2014 Aug; 64(2): 278–89.10.1053/j.ajkd.2014.02.025
    1. 5. Nochaiwong S, Ruengorn C, Koyratkoson K, Thavorn K, Awiphan R, Chaisai C, et al. Thai Renal Outcomes Research (THOR) Investigators. A Clinical Risk Prediction Tool for Peritonitis-Associated Treatment Failure in Peritoneal Dialysis Patients. Sci Rep. 2018 Oct 4; 8(1): 1479710.1038/s41598-018-33196-2