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. 2022 Mar;31(3):106297.
doi: 10.1016/j.jstrokecerebrovasdis.2021.106297. Epub 2022 Jan 13.

Adherence to Guideline-Recommended Cancer Screening in Stroke Survivors: A Nationwide Analysis

Marialaura Simonetto  1 , Stephanie Rutrick  1 , Natalie M LeMoss  1 , Kelsey N Lansdale  1 , Scott T Tagawa  2 , Hooman Kamel  1 , Neal Parikh  1 , Babak B Navi  3
Affiliations

Adherence to Guideline-Recommended Cancer Screening in Stroke Survivors: A Nationwide Analysis

Marialaura Simonetto et al. J Stroke Cerebrovasc Dis. 2022 Mar.

Abstract

Objectives: Cancer can present as stroke. Several cancer types have established screening guidelines. We investigated adherence to guideline-recommended cancer screening in stroke survivors versus the general population.

Materials and methods: We performed a cross-sectional analysis using 2012-2018 data from the CDC's Behavioral Risk Factor Surveillance System (BRFSS) survey. BRFSS is a nationally-representative telephone survey of non-institutionalized Americans that collects data about health conditions and behaviors, including cancer screening. We defined guideline-recommended colorectal, lung, and breast cancer screening based on the U.S. Preventive Services Task Force recommendations. We used survey-specific methods to estimate up-to-date screening rates for those with and without prior stroke. We used logistic regression to estimate the odds of up-to-date screening in stroke survivors compared to those without history of stroke after adjustment for potential confounders.

Results: Among 1,018,440 respondents eligible for colorectal cancer screening, 66% were up-to-date. Among 6,880 respondents eligible for lung cancer screening, 16% were up-to-date. Among 548,434 women eligible for breast cancer screening, 78% were up-to-date. After adjustment for demographics and confounders, stroke survivors were more likely to have up-to-date colorectal cancer screening (OR, 1.10; 95% CI, 1.05-1.16), equally likely to undergo lung cancer screening (OR, 0.99; 95% CI, 0.62-1.59), and less likely to undergo breast cancer screening (OR, 0.87; 95% CI, 0.80-0.94).

Conclusions: In a nationwide analysis, stroke survivors had similar suboptimal adherence to guideline-recommended cancer screening as the general population.

Keywords: Cancer; Malignancy; Neoplasm; Screening; Stroke.

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Conflict of interest statement

Declaration of Competing Interest Hooman Kamel serves as co-PI for the NIH-funded ARCADIA trial which receives in-kind study drug from the BMS-Pfizer Alliance and in-kind study assays from Roche Diagnostics, serves as Deputy Editor for JAMA Neurology, serves as a steering committee member of Medtronic's Stroke AF trial (uncompensated), and serves on an endpoint adjudication committee for a trial of empagliflozin for Boehringer-Ingelheim. Neal Parikh has received personal fees for medicolegal consulting on stroke. Babak Navi has received personal fees for medicolegal consulting on stroke. The other authors have no disclosures.

References

    1. Navi BB, DeAngelis LM, Segal AZ. Multifocal strokes as the presentation of occult lung cancer. J Neurooncol 2007;85:307–309. - PubMed
    1. Navi BB, Kawaguchi K, Hriljac I, et al. Multifocal stroke from tumor emboli. Arch Neurol2009;66:1174–1175. - PubMed
    1. Virani SS, Alonso A, Benjamin EJ, et al. Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association. Circulation 2020;141:e139–e596. - PubMed
    1. Navi BB, Reiner AS, Kamel H, et al. Risk of Arterial Thromboembolism in Patients With Cancer. J Am Coll Cardiol 2017;70:926–938. - PMC - PubMed
    1. Navi BB, Reiner AS, Kamel H, et al. Association between incident cancer and subsequent stroke. Ann Neurol 2015;77:291–300. - PMC - PubMed

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