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. 2022 Oct;26(5):2703-2715.
doi: 10.1007/s11030-021-10360-x. Epub 2022 Jan 16.

Heterogeneous catalyst SiO2-LaCl3·7H2O: characterization and microwave-assisted green synthesis of α-aminophosphonates and their antimicrobial activity

S K Thaslim Basha  1 , Reddi Mohan Naidu Kalla  2 , M Varalakshmi  3 , H Sudhamani  1 , Rama Moorthy Appa  4 , Sung Chul Hong  5 , Chamarthi Naga Raju  6
Affiliations

Heterogeneous catalyst SiO2-LaCl3·7H2O: characterization and microwave-assisted green synthesis of α-aminophosphonates and their antimicrobial activity

S K Thaslim Basha et al. Mol Divers. 2022 Oct.

Abstract

Silica-supported lanthanum (III) chloride (SiO2-LaCl3·7H2O) was prepared and characterized by infrared spectroscopy, X-ray diffraction analysis, scanning electron microscope, energy-dispersive X-ray spectroscopy, thermogravimetric analysis and differential thermal analysis techniques. The catalytic activity of this silica-supported lanthanum (III) chloride was investigated in a one-pot three-component Kabachnik-Fields reaction. A library of new α-aminophosphonates was prepared employing various benzothiazole and thiadiazole amines, different substituted aldehydes and diethylphosphite under solvent-free conditions using conventional/microwave methods with good to excellent yields (85-97%). The advantages of this catalyst are that it is environmentally benign, economically inexpensive, and easy to prepare, gives high yields and high purity is less time-consuming, offers easy purification is reusable and enables products to be obtained by simple recrystallization without column chromatography.

Keywords: Anti-microbial activity; Heterogeneous catalyst; Microwave condition; Novel α-aminophosphonates; Recyclability; Sustainable method.

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