Can PCSK7 be A New Pharmaceutical Target?

Affiliations

Editorial

Masa-Aki Kawashiri. J Atheroscler Thromb. 2022.

. 2022 Sep 1;29(9):1265-1267.

doi: 10.5551/jat.ED188. Epub 2022 Jan 15.

No abstract available

Comment on

Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication.
Furuhashi M, Kataoka Y, Nishikawa R, Koyama M, Sakai A, Higashiura Y, Tanaka M, Saitoh S, Shimamoto K, Ohnishi H. Furuhashi M, et al. J Atheroscler Thromb. 2022 Sep 1;29(9):1275-1284. doi: 10.5551/jat.63159. Epub 2021 Sep 25. J Atheroscler Thromb. 2022. PMID: 34565765 Free PMC article.

1. Diel AM, Day C. Cause, Pathogenesis, and treatment of nonalcoholic steatohepatitis. N Engl J Med, 2017; 377: 2063-2072 - PubMed
1. Anstee QM, Seth D, Day CP. Genetic Factors that affect risk of alcoholic and nonalcoholic fatty liver disease. Gastroenterology, 2016; 150: 1728-1744.e7 - PubMed
1. Valenti L, Fracanzani AL, Bugianesi E, Dongiovanni P, Galmozzi E, Vanni E, Canavesi E, Lattuada E, Roviaro G, Marchesini G, Fargion S. HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease. Gastroenterology, 2010; 138: 905-912 - PubMed
1. Artenstein AW, Opal SM. Proprotein convertases in health and disease. N Engl J Med, 2011; 365: 2507-2518 - PubMed
1. Abifadel M, Varret M, Rabès JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, Derré A, Villéger L, Farnier M, Beucler I, Bruckert E, Chambaz J, Chanu B, Lecerf JM, Luc G, Moulin P, Weissenbach J, Prat A, Krempf M, Junien C, Seidah NG, Boileau C. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet, 2003; 34: 154-156 - PubMed