Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 17;21(6):e41.
doi: 10.4110/in.2021.21.e41. eCollection 2021 Dec.

Correlation between Reactogenicity and Immunogenicity after the ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccination

So Yun Lim  1 , Ji Yeun Kim  1 , Soonju Park  2 , Ji-Soo Kwon  1 , Ji Young Park  1 , Hye Hee Cha  1 , Mi Hyun Suh  1 , Hyun Jung Lee  1 , Joon Seo Lim  3 , Seongman Bae  1 , Jiwon Jung  1 , Nakyung Lee  2 , Kideok Kim  2 , David Shum  2 , Youngmee Jee  2 , Sung-Han Kim  1
Affiliations

Correlation between Reactogenicity and Immunogenicity after the ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccination

So Yun Lim et al. Immune Netw. .

Abstract

Correlation between vaccine reactogenicity and immunogenicity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Thus, we investigated to determine whether the reactogenicity after coronavirus disease 2019 vaccination is associated with antibody (Ab) titers and T cell responses. This study was prospective cohort study done with 131 healthcare workers at tertiary center in Seoul, South Korea. The degrees of the local reactions after the 1st and 2nd doses of ChAdOx1 nCov-19 (ChAdOx1) vaccination were significantly associated with the S1-specific IgG Ab titers (p=0.003 and 0.01, respectively) and neutralizing Ab (p=0.04 and 0.10, respectively) in age- and sex-adjusted multivariate analysis, whereas those after the BNT162b2 vaccination did not show significant associations. T cell responses did not show significant associations with the degree of reactogenicity after the ChAdOx1 vaccination or the BNT162b2 vaccination. Thus, high degree of local reactogenicity after the ChAdOx1 vaccine may be used as an indicator of strong humoral immune responses against SARS-CoV-2.

Keywords: Antibody response; COVID-19; Injection site reaction; Neutralizing antibody; Vaccine.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors declare no potential conflicts of interest.

Figures

Figure 1
Figure 1. Correlation of reactogenicity and immunogenicity of COVID-19 vaccine after 1st dose. Solid lines denote the mean and dotted lines denote the 95% confidential intervals. (A) SARS-CoV-2 S1-specific IgG and local reaction. (B) SARS-CoV-2 S1-specific IgG and systemic reaction. (C) Neutralizing Ab and local reaction. (D) Neutralizing Ab and systemic reaction.
Figure 2
Figure 2. Correlation of reactogenicity and immunogenicity of COVID-19 vaccine after 2nd dose. Solid lines denote the mean and dotted lines denote the 95% confidential intervals. (A). SARS-CoV-2 S1-specific IgG and local reaction. (B) SARS-CoV-2 S1-specific IgG and systemic reaction. (C) Neutralizing Ab and local reaction. (D) Neutralizing Ab and systemic reaction.
See this image and copyright information in PMC

References

    1. Bae S, Lee YW, Lim SY, Lee JH, Lim JS, Lee S, Park S, Kim SK, Lim YJ, Kim EO, et al. Adverse reactions following the first dose of Chadox1 nCov-19 vaccine and BNT162b2 vaccine for healthcare workers in South Korea. J Korean Med Sci. 2021;36:e115. - PMC - PubMed
    1. Hervé C, Laupèze B, Del Giudice G, Didierlaurent AM, Tavares Da Silva F. The how's and what's of vaccine reactogenicity. NPJ Vaccines. 2019;4:39. - PMC - PubMed
    1. Kim SH, Bang JW, Park KH, Park WB, Kim HB, Kim NJ, Jee Y, Cho H, Oh MD, Choe KW. Prediction of residual immunity to smallpox, by means of an intradermal skin test with inactivated vaccinia virus. J Infect Dis. 2006;194:377–384. - PubMed
    1. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. Smallpox and its eradication. Geneva: World Health Organization; 1988.
    1. Wulff H, Chin TD, Wenner HA. Serologic responses of children after primary vaccination and revaccination against smallpox. Am J Epidemiol. 1969;90:312–318. - PubMed