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Review
. 2021 Oct 8;11(6):609-625.
doi: 10.4103/jispcd.JISPCD_168_21. eCollection 2021 Nov-Dec.

Association Between Periodontitis and Metabolic Syndrome in Females: A Systematic Review and Meta-analysis

Ghousia Sayeed  1 , Sheeja S Varghese  2
Affiliations
Review

Association Between Periodontitis and Metabolic Syndrome in Females: A Systematic Review and Meta-analysis

Ghousia Sayeed et al. J Int Soc Prev Community Dent. .

Abstract

Background: Metabolic syndrome (MetS) and periodontal diseases (PDs) have shown a bidirectional and vice versa relationship. Hence, this study aimed to identify the extent and magnitude between MetS and PDs in females.

Materials and methods: A published literature was explored by considering case-control, cross-sectional, and cohort studies that involved patients with measurements of MetS and PD. Ovid MEDLINE, EMBASE, LILACS, and Cochrane Library databases were used for the search. This study examined the relationship between the MetS and PD among females.

Results: Of the initial 4150 titles screened, a total of 37 reported papers were eligible for quantitative review. A gender-wise analysis of the findings revealed a crude odds ratio (OR) of 1.385 [95% confidence interval (CI): 1.043-1.839, I 2 = 94.61%, P < 0.001] for the females relative to the average OR of 1.54 (95% CI: 1.39-1.71, I 2 = 90.95%, P < 0.001). Further subgroup analysis for directionality in females revealed the crude ORs of 1.28 (95% CI: 0.91-1.79, I 2 = 96.44%, P < 0.001) for the relationship between PD and MetS, whereas an OR of 2.12 (95% CI: 0.78-5.73, I 2 = 88.31%, P < 0.001) was found between MetS and PDs.

Conclusion: This study lacks convincing proof of a link between MetS and PDs in females when compared with an overall association between MetS and PDs. Directionality indicated higher odds of linking between MetS and PD than PD and MetS among females. Further longitudinal and treatment trials are needed to confirm the association among females.

Keywords: Females; metabolic syndrome; periodontal diseases; systematic review.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the search studies for systematic review
Figure 2
Figure 2
Forest plot of gender and MetS
Figure 3
Figure 3
Forest plot of PD to MetS in females
Figure 4
Figure 4
Forest plot of overall PD to MetS
Figure 5
Figure 5
Forest plot of MetS to PD in females
Figure 6
Figure 6
Forest plot of overall MetS to PD
See this image and copyright information in PMC

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