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. 2022 Mar;194(3):1120-1135.
doi: 10.1007/s12010-022-03816-9. Epub 2022 Jan 17.

Myrobalan-Mediated Nanocolloids in Controlling Marine Pathogens

S Ranjani  1 , Pradeep Parthasarathy  1 , P Rameshkumar  2 , S Hemalatha  3
Affiliations

Myrobalan-Mediated Nanocolloids in Controlling Marine Pathogens

S Ranjani et al. Appl Biochem Biotechnol. 2022 Mar.

Abstract

Aquaculture production is affected by disease outbreak, which affects the production, profitability, and sustainability of the global aquaculture industry. Antibiotics have been widely used to control various infectious diseases. Indiscriminate usage of antibiotics results in development of antibiotic resistance in pathogens. This current study aims to synthesize myrobalan-mediated green silver nanocolloids (MBNc) by using the extract of three myrobalans and characterized by using various physiochemical techniques. Antibacterial potential of MBNc was screened in vibriosis causing pathogens (V. harveyi, V. alginolyticus, V. Parahaemolyticus), and foodborne pathogen S. haemolyticus, isolated from infected fish. Further, the presence of ESBL genes including CTX-M-15 and Amp C was analyzed in control and MBNc-treated strains. From our studies, it was observed that MBNc was very effective in controlling the growth. MBNc confirmed the anti-biofilm property in all tested marine pathogens and effectively abolish the genes encoding CTX-M-15 in tested pathogens. Thus, MBNc can be formulated to control the growth of marine pathogens and it can be used as an alternative to antibiotics to prevent infection in cage culturing and aquafarming.

Keywords: Foodborne pathogens; Myrobalans; S. haemolyticus; Silver nanocolloids; V. alginolyticus; V. harveyi; V. parahaemolyticus.

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